Reviews | Objective | Type of Studies included (number) | Cochrane/non-Cochrane | Pooled Data (Y/N) | Outcomes reported |
---|---|---|---|---|---|
Imdad 2011[8] | To assess the effectiveness of breastfeeding promotion interventions on breastfeeding rates in early infancy. | RCTs and qRCTs: 53 | Non-Cochrane | Yes | EBF at 4-6 weeks postpartum |
Dyson 2005[9] | To evaluate the effectiveness of interventions which aim to encourage women to breastfeed in terms of changes in the number of women who start to breastfeed. | RCTs: 7 | Cochrane | Yes | Increasing breastfeeding initiation rates |
Haroon 2013[10] | A systematic literature search was conducted for RCTs and quasi-experimental studies comparing breastfeeding education or support to routine care. The | RCTs: 21 | Non-Cochrane | Yes | Exclusive breastfeeding rates |
Kramer 2012[16] | To assess the effects on child health, growth, and development, and on maternal health, of exclusive breastfeeding for six months versus exclusive breastfeeding for three to four months with mixed breastfeeding (introduction of complementary liquid or solid foods with continued breastfeeding) thereafter through six months. | RCTs: 2 Observational studies: 18 | Cochrane | Yes | Exclusive breastfeeding rates |
Lassi 2013[20] | The effect of complementary feeding (CF) (fortified or unfortified, but not micronutrients alone) and education on CF on children less than 2 years of age in low and middle income countries (LMIC). | RCTs and qRCTs: 16 | Non-Cochrane | Yes | HAZ, WAZ, stunting |
Bhutta 2008[21] | The effect of complementary feeding (CF) in food secure and food insecure population | RCTs: 7 | Cochrane | Yes | HAZ, WAZ, stunting |
Lengler 2004[22] | To assess the impact of insecticide-treated bed nets or curtains on mortality, malarial illness (life-threatening and mild), malaria parasitaemia, anaemia, and spleen rates. | RCTs: 14 | Cochrane | Yes | Mortality, malarial illness (life-threatening and mild), malaria parasitaemia, anaemia, and spleen rates. |
Meremikwu 2012[24] | To evaluate the effects of IPTc to prevent malaria in preschool children living in endemic areas with seasonal malaria transmission. | RCTs: 7 | Cochrane | Yes | Clinical malaria episode, all-cause mortality |
Thwing 2011[25] | We performed systematic literature reviews of published studies in P. falciparum endemic settings to determine the protective efficacy (PE) of ACT treatment against malaria deaths among children with uncomplicated malaria, as well as the PE of effective case management including parenteral quinine against malaria deaths among all hospitalized children. | Ata sources | Non-Cochrane | Yes | Malaria mortality |
Eisele 2010[26] | To estimate the effect of ITNs and IRS on preventing malaria-attributable mortality in children 1–59 months, and to estimate the effect of ITNs and IPTp on preventing neonatal and child mortality through improvements in birth outcomes. | RCTs: 14 | Non-Cochrane | Yes | Protective efficacy, malaria-attributable mortality 1–59 months, prevention interventions in pregnancy |
Mathanga 2011[27] | To compare intermittent preventive treatment regimens for malaria in HIV-positive pregnant women living in malaria-endemic areas. | RCTs: 2 | Cochrane | Yes | Maternal anaemia, low birth weight, and neonatal mortality |
Grimwade 2006[28] | To assess the effects of routinely administered cotrimoxazole on death and illness episodes in children with HIV infection, and in infants of HIVinfected mothers. | RCTs: - | Cochrane | No | - |
Siefried 2011[30] | To determine whether, and to what extent, antiretroviral regimens aimed at decreasing the risk of mother-to-child transmission of HIV infection achieve a clinically useful decrease in transmission risk, and what effect these interventions have on maternal and infant mortality and morbidity. | RCTs: 25 | Cochrane | Yes | Reduction in the proportion infected: |
Adeitfa 2009[31] | To assess the effects of routinely administered cotrimoxazole on death and illness episodes in children with HIV infection, and in infants of HIV infected mothers. | RCTs and qRCT: 0 | Cochrane | No | - |
Chetty 2010[84] | The objective of the systematic review was to pool and evaluate the data on the effectiveness of different infant feeding practices from birth to 18months in achieving HIV-free survival of HIV-exposed infants. | RCTS:17 Observational studies: 17 Secondary articles: 18 | Non-Cochrane | Yes | Mixed breastfeeding/replacement feeding up to 6 months of life |
Soares-Weiser 2012[34] | To evaluate rotavirus vaccines approved for use (Rotarix, RotaTeq, and Lanzhou Lamb Rotavirus (LLR)) for preventing rotavirus diarrhoea. | RCTs: 34 | Cochrane | Yes | Rotavirus diarrhoea, all-cause diarrhoea (severe cases), and hospitalizations and need for medical attention |
Soares-Weiser 2004[35] | To assess rotavirus vaccines in relation to preventing rotavirus diarrhoea, death, and adverse events. | RCTs: 64 | Cochrane | Yes | Rotavirus diarrhoea, all-cause diarrhoea (severe cases), and hospitalizations and need for medical attention |
Munos 2010[36] | To assess efficacy and effectiveness trials of rotavirus vaccines | RCTs: 25 | Non-Cochrane | Yes | Hospitalizations |
Das 2013[37] | To assess efficacy and effectiveness trials of vaccines | RCTs and qRCTs: 24 | Non-Cochrane | Yes | Mortality, rota-virus specific moetality |
Imdad 2011[42] | The purpose of this paper was to get a point estimate of efficacy of vitamin A supplementation in reducing cause specific mortality by using Child Health Epidemiology Reference Group (CHERG) guidelines. | RCTs: 21 | Non-Cochrane | Yes | All-cause mortality, diarrhea specific mortality, meningitis, and pneumonia specific mortality |
Imdad 2010[43] | To evaluate the effect of vitamin A supplementation (VAS) for preventing morbidity and mortality in children aged 6 months to 5 years. | RCTs: 43 | Cochrane | Yes | All-cause mortality, diarrhea specific mortality, meningitis, and pneumonia specific mortality |
Mayo-Wilson 2011[44] | To determine if vitamin A supplementation is associated with reductions in mortality and morbidity in children aged 6 months to 5 years. | RCTs: 43 | Cochrane | Yes | All-cause mortality, diarrhea specific mortality, meningitis, and pneumonia specific mortality |
Ahmed 2010[46] | To evaluate the management of severe acute malnutrition according to WHO guidelines | RCTs: 25 | Non-Cochrane | Yes | Mortality, weight gain |
Lenters 2013[47] | To evaluate the effectiveness of interventions for SAM including the World Health Organization (WHO) protocol for inpatient management and community-based management with ready-to-use-therapeutic food (RUTF), as well as interventions for MAM in children under five years in low- and middle-income countries. | RCTs: 14 | Non-Cochrane | Yes | Case fatality |
Theodaratou 2010[49] | To assess the effect of pneumonia case management on mortality from childhood pneumonia. | RCTs: 25 | Non-Cochrane | Yes | All-cause mortality, pneumonia specific mortality |
Sazawal 2003[50] | This meta-analysis provides estimates of mortality impact of the case-management approach proposed by WHO. | RCTs: 7 | Non-Cochrane | Yes | All-cause mortality, pneumonia specific mortality |
Das 2013[51] | To estimate the effect of community based interventions including community case management on the coverage of various commodities and on mortality due to diarrhea and pneumonia. | RCTs and qRCTs: 24 | Non-Cochrane | Yes | Care seeking for pneumonia and diarrhea, treatment failure, case management |
Fawzi 1993[52] | A two-part meta-analysis of studies examining the relationship of vitamin A supplementation and child mortality. | RCTs: 12 | Non-Cochrane | Yes | All-cause mortality, |
Sudfeld 2010[53] | To determine effect estimates of measles vaccine and vitamin A treatment for the Lives Saved Tool (LiST). | RCTs and qRCT: 525 | Non-Cochrane | Yes | Preventing measles disease |
Brown 2004[54] | To determine the efficacy of intervention with high-dose vitamin A as an adjunct to standard treatment on outcome in acute lower respiratory tract infection in children in developing countries. | RCTs: 5 | Non-Cochrane | Yes | Faster recovery; oxygen requirement; raised respiratory rate; hospital stay, mortality |
Wu 2005[55] | To determine whether adjunctive vitamin A is effective in children diagnosed with non-measles pneumonia. | RCTs: 6 | Cochrane | Yes | Mortality, hospital stay |
Grotto 2003[56] | To perform an updated meta-analysis of the effect of vitamin A supplementation on childhood morbidity from respiratory tract infections and diarrhea. | RCTs: 9 | Non-Cochrane | Yes | Incidence of diarrhea, incidence of respiratory tract infections |
Chen 2008[57] | To assess the effectiveness and safety of vitamin A for preventing acute LRTIs in children up to seven years of age. | RCTs: 10 | Cochrane | Yes | Incidence of acute LRTI in one study; an increase in cough and fever; and increased symptoms of cough and rapid breathing |
Lamberti 2013[58] | To quantify the protective effects of breastfeeding exposure against pneumonia incidence, prevalence,hospitalizations and mortality | Prospective cohort= 7 Case-control = 3 | Non-Cochrane | Yes | Pneumonia mortality |
Yakoob 2011[62] | To determine all-cause mortality and cause-specific mortality and morbidity in children under five in developing countries for preventive zinc supplementation. | RCTs: 8 | Cochrane | Yes | Diarrhea-specific mortality and pneumonia-specific mortality |
Lazzirini 2013[66] | To evaluate oral zinc supplementation for treating children with acute or persistent diarrhoea | RCTs: 18 | Cochrane | Yes | Diarrhea duration |
Gregorio 2009[67] | To compare polymer-based ORS with glucose-based ORS for treating acute watery diarrhoea. | RCTs: 34 | Cochrane | Yes | Unscheduled intravenous infusions, duration of diarrhea |
Hartling 2006[68] | To compare oral with intravenous therapy for treating dehydration due to acute gastroenteritis in children. | RCTs: 17 | Cochrane | Yes | Intravenous infusions, duration of diarrhea, hospital stay, oral intake |
Hahn 2002[69] | To compare reduced osmolarity oral rehydration solution with the World Health Organization recommended strength for treating diarrhoea in children. | RCTs: 41 | Cochrane | Yes | Unscheduled intravenous infusions |
Lenters 2013[70] | To understand which interventions are effective in promoting the use of ORS, and where there are gaps in the literature | RCTs: 19 | Non-Cochrane | Yes | Diarrhea episodes |
Das 2013[71] | To estimate the effect of antiemetics in gastroenteritis in children | RCTs: 7 | Non-Cochrane | Yes | Incidence of vomiting and hospitalization |
Christopher 2010[72] | To evaluate the efficacy and safety of antibiotics for treating Shigella dysentery. | RCTs: 16 | Cochrane | Yes | Incidence of diarrhea |
Traa 2010[73] | To review the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. | RCTs: 19 | Non-Cochrane | Yes | Rates of treatment failure, bacteriological failure and bacteriological relapse |
Das 2013[74] | To review the literature reporting the effect of antibiotics for the treatment of diarrhea due to cholera, Shigella and Cryptosporidium in children under five years | RCTs: 6 | Non-Cochrane | Yes | Mortality and cause specific mortality |
Musekiwa 2011[77] | To compare the safety and efficacy of ORS ≤270 with ORS ≥ 310 for treating dehydration due to cholera. | RCTs: 7 | Cochrane | Yes | Biochemical hyponatraemia |