Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: A prospective study

Table 3 Metabolic variables before and after 4 months with the CSP

Variable (RV)	Basal	4 months	p	Reference values
Glucose [mg/dl]	89.5 (73.0-110.0)	92.2 (80.0-104.0)	0.289	65-114
Urea [mg/dl]	19.2 (8.6-35.1)	20.4 (12.8-28.8)	0.362	15-39
Creatinine [mg/dl]	0.55 (0.4-0.8)	0.59 (0.5-0.8)	0.071	0.5-1.2
Uric acid [mg/dl]	4.3 (2.8-6.5)	4.1 (3.1-6.1)	0.299	2.6-7.2
TG [mg/dl]	132.3 (50.7-307.0)	149.7 (82.3-224.8)	0.174	54-214
TC [mg/dl]	171.9 (142.1-222.3)	179.7 (137.8-235.7)	0.201	140-220
HDL-C [mg/dl]	41.8 (22.5-64.1)	44.4 (22.9-67.1)	0.220	21-75
LDL-C [mg/dl]	104.7 (58.9-143.5)	105.4 (73.1-152.1)	0.906	56-155
VLDL-C [mg/dl]	26.3 (10.1-62.0)	29.9 (16.5-45.0)	0.192
AI	4.41 (2.9-8.4)	4.33 (2.9-7.6)	0.613	<4
TB [mg/dl]	0.64 (0.2-1.2)	0.51 (0.2-0.9)	0.048	0.2-1.0
DB [mg/dl]	0.09 (0.0-0.2)	0.09 (0.0-0.2)	0.797	0.0-0.2
IB [mg/dl]	0.55 (0.1-1.0)	0.42 (0.1-0.9)	0.032
SGOT [U/l]	22.4 (15.6-37.5)	22.5 (15.0-46.3)	0.974	15-37
SGPT [U/l]	19.6 (8.0-46.8)	17.6 (9.6-38.8)	0.321	8-35
AP [U/l]	68.0 (42.7-98.8)*	60.4 (40.5-86.9)	0.025	37-110
LDH [U/l]	129.8 (80.6-166.8)*	120.8 (86.0-162.5)	0.053	106-274
GGT [U/l]	18.4 (9.6-31.9)	17.1 (5.6-34.5)	0.259	5-24
TP [g/dl]	7.0 (5.9-8.6)	6.9 (6.0-8.0)	0.431	6.7-8.2
Alb [g/dl]	4.1 (3.4-4.9)	3.9 (3.3-4.6)	0.061	3.8-5.1
Glb [g/dl]	2.94 (2.3-3.8)	2.98 (2.5-3.5)	0.721

Results are expressed as median (percentiles: 2.5-97.5). Reference values (RV) are showed in the fifth column. Significant p values are shown in bold. Creatinine (p < 0.012), triglycerides (TG; p = 0.002), serum glutamic oxaloacetic transaminase (SGOT; p < 0.001), serum glutamic pyruvic transaminase (SGPT; p < 0.001), very-low-density lipoprotein cholesterol (VLDL-C; p = 0.002) and high sensitivity C-reactive protein (hsCRP; p < 0.001), had an abnormal distribution. CSP: contraceptive skin patch; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; AI: atherogenic index; DB: direct bilirubin; IB: indirect bilirubin; TB: total bilirubin; GGT: gammaglutamyl transferase; AP: alkaline phosphatase; LDH: lactate dehydrogenase; TP: total proteins; Alb: albumin; Glb: globulins. Kolmogorov Smirnov test was used to establishing the distribution of variables. Mann-Whitney U test and Wilcoxon test were used in order to analyze non-parametric values. Student t test and paired t tests were used for parametric variables.

ISSN: 1742-4755