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Table 5 Thyroid screening, leptin, adiponectin, insulin, C peptide, IGF-1, and hsCRP before and after 4 months with the CSP

From: Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: A prospective study

Variable

Basal

4 months

p

Reference values

TSH (μU/ml)

2.4 (0.8-6.2)

1.9 (0.7-3.9)

0.158

0.34-5.60

T4 (μg/dl)

8.5 (6.1-11.5)

9.2 (7.0-11.4)

0.072

6.09-12.23

T3 (ng/dl)

124.2 (68.1-188.3)

148.2 (110.0-220.2)

0.001

75-250

FTI

8.2 (5.7-11.9)

8.3 (6.9-10.0)

0.864

4.5-15.0

PBI (μg/dl)

5.5 (4.0-7.5)

6.0 (4.6-7.4)

0.070

3.90-7.80

TU (%)

1.0 (0.8-1.2)

0.8 (0.8-1.0)

0.009

0.75-1.25

Anti-Tg (μU/ml)

8.1 (5.0-333.1)

7.1 (5.1-230.4)

0.159

5-100

Anti-TPO (μU/ml)

0.7 (0.3-404.7)

0.7 (0.3-378.3)

0.915

0-9

Insulin (μU/ml)

8.7 (3.8-33.2)

9.2 (4.7-19.5)

0.547

5-30

C peptide (ng/ml)

2.7 (1.6-5.7)

2.8 (1.8- 4.2)

0.559

0.5-3.0

IGF-1 C (pg/ml)

227.0 (89.3-499.0)

225.4 (16.9-369.3)

0.775

115-307

Leptin (ng/ml)

9.5 (1.9-24.2)

8.9 (3.8-30.0)

0.090

4.1-22.4

Adiponectin (μg/ml)

16.6 (6.5-41.8)

17.9 (5.2-32.1)

0.409

3.9-25.6

hsCRP (mg/dl)

0.28 (0.01-1.0)

0.51 (0.1-1.3)

0.013

0.0-0.8

  1. Results are expressed as median (percentiles: 2.5-97.5). Significant p values are shown in bold. With the exception of total thyroxine (T4; p = 0.373), thyroid uptake (TU; p = 0.748) and serum protein-bound iodine (PBI; p = 0.594), all variables had an abnormal distribution (p < 0.050). TSH: thyroid-stimulating hormone; T3: total triiodothyronine; FTI: free thyroxine index; anti-Tg: anti-thyroglobulin antibodies; anti-TPO: anti-thyroid microsomal antibodies; IGF-1: insulin growth factor-1; hsCRP: high-sensitivity C-reactive protein (hsCRP). Kolmogorov Smirnov test was used to establishing the distribution of variables. Mann-Whitney U test and Wilcoxon test were used to analyze non-parametric values. Student t test and paired t tests were used for parametric variables.