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Table 3 Distribution of insulin resistance, glucose tolerance, MetS parameters and family history of T2DM among PCOS phenotypes and control

From: A case–control observational study of insulin resistance and metabolic syndrome among the four phenotypes of polycystic ovary syndrome based on Rotterdam criteria

Variables PCOS (n = 263) A (n = 139) B (n = 10) C (n = 36) D (n = 78) Control (n = 263) P-value PCOS phenotypes vs controls
Fasting insulin ≥20 μU/mL 64 (24.3) 33 (23.7) 4 (40) 10 (27.8) 17(21.8) 17 (6.5) <0.001
Fasting glucose/Fasting insulin ≤4.5 61 (23.2) 32 (23) 4 (40) 10 (27.8) 15(19.2) 17 (6.5) < 0.001
HOMA-IR ≥ 3.8 90 (34.2) 49 (35.3) 5 (50) 12 (33.3) 24(30.8) 36 (13.7) < 0.001
Ratio 2-h glucose/2-h insulin ≤1 61 (23.2) 40 (28.8) 3 (30) 9 (25) 9 (11.5) 13(4.9) < 0.001
Normal GTT 176 (66.9) 88 (63.3) 5 (50) 26 (72.2) 57(73.1) 196(74.5) 0.092
Prediabetes (IFG and/or IGT) 75 (28.5) 46 (33.1) 5 (50) 8 (22.2) 16(20.5) 61(23.2)
Type 2 diabetes mellitus 12 (4.6) 5 (3.6) 0 (0) 2 (5.6) 5 (6.4) 6 (2.3)
Insulin resistance (IR) 112 (42.6) 64 (46)* 5 (50)* 17(47.2)* 26(33.3)* 45(17.1) <0.001
Metabolic syndrome (MetS) 141 (53.6) 81 (58.3)** 8(80)** 17(47.2)** 35(44.9)** 86(32.7) <0.001
Family history of T2DM 131 (49.8) 65 (46.8)+ 4 (40)+ 18 (50)+ 44(56.4)+ 104 (39.5) 0.094
  1. Data are shown as n (%). P-values were calculated using Chi-square test.
  2. *Insulin resistance frequencies did not differ significantly between the PCOS phenotypes (P = 0.271).
  3. **Metabolic syndrome frequencies did not differ significantly between phenotypes (P = 0.069).
  4. +Family history of T2DM frequencies did not differ significantly between phenotypes (P = 0.525).
  5. (Note: (i) Phenotype A (O + H + P), (ii) Phenotype B (O + H), (iii) Phenotype C (H + P) and (iv) Phenotype D (O + P). IFG: impaired fasting glucose, IGT: impaired glucose tolerance.