Table 3 Distribution of insulin resistance, glucose tolerance, MetS parameters and family history of T2DM among PCOS phenotypes and control
Variables | PCOS (n = 263) | A (n = 139) | B (n = 10) | C (n = 36) | D (n = 78) | Control (n = 263) | P-value PCOS phenotypes vs controls |
|---|---|---|---|---|---|---|---|
Fasting insulin ≥20 μU/mL | 64 (24.3) | 33 (23.7) | 4 (40) | 10 (27.8) | 17(21.8) | 17 (6.5) | <0.001 |
Fasting glucose/Fasting insulin ≤4.5 | 61 (23.2) | 32 (23) | 4 (40) | 10 (27.8) | 15(19.2) | 17 (6.5) | < 0.001 |
HOMA-IR ≥ 3.8 | 90 (34.2) | 49 (35.3) | 5 (50) | 12 (33.3) | 24(30.8) | 36 (13.7) | < 0.001 |
Ratio 2-h glucose/2-h insulin ≤1 | 61 (23.2) | 40 (28.8) | 3 (30) | 9 (25) | 9 (11.5) | 13(4.9) | < 0.001 |
Normal GTT | 176 (66.9) | 88 (63.3) | 5 (50) | 26 (72.2) | 57(73.1) | 196(74.5) | 0.092 |
Prediabetes (IFG and/or IGT) | 75 (28.5) | 46 (33.1) | 5 (50) | 8 (22.2) | 16(20.5) | 61(23.2) | |
Type 2 diabetes mellitus | 12 (4.6) | 5 (3.6) | 0 (0) | 2 (5.6) | 5 (6.4) | 6 (2.3) | |
Insulin resistance (IR) | 112 (42.6) | 64 (46)* | 5 (50)* | 17(47.2)* | 26(33.3)* | 45(17.1) | <0.001 |
Metabolic syndrome (MetS) | 141 (53.6) | 81 (58.3)** | 8(80)** | 17(47.2)** | 35(44.9)** | 86(32.7) | <0.001 |
Family history of T2DM | 131 (49.8) | 65 (46.8)+ | 4 (40)+ | 18 (50)+ | 44(56.4)+ | 104 (39.5) | 0.094 |