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Table 1 Sample size scenarios

From: Active management of the third stage of labour without controlled cord traction: a randomized non-inferiority controlled trial

Blood loss ≥ 1000 ml with full amtsl Blood loss ≥ 1000 ml with Expectant Estimated impact of Full AMTSL Proportion (of full AMTSL effect) retained by the simplified package Δ (Difference to exclude to claim equivalence) Total N for 80% Power Power with total N = 20,000 Power with total N = 25,000
1.5 3.0 1.5 0.7 0.45 22,908 75% 83%
1.5 3.5 2.0 0.75 0.50 18,555 83% 90%
1.5 4.0 2.5 0.8 0.50 18,555 83% 90%