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Table 1 Sample size scenarios

From: Active management of the third stage of labour without controlled cord traction: a randomized non-inferiority controlled trial

Blood loss ≥ 1000 ml with full amtsl

Blood loss ≥ 1000 ml with Expectant

Estimated impact of Full AMTSL

Proportion (of full AMTSL effect) retained by the simplified package

Δ (Difference to exclude to claim equivalence)

Total N for 80% Power

Power with total N = 20,000

Power with total N = 25,000

1.5

3.0

1.5

0.7

0.45

22,908

75%

83%

1.5

3.5

2.0

0.75

0.50

18,555

83%

90%

1.5

4.0

2.5

0.8

0.50

18,555

83%

90%