Ovarian stimulation with human and recombinant gonadotropin – comparison of in vitro fertilization efficiency with use of time-lapse monitoring

Wdowiak, Artur; Bojar, Iwona

doi:10.1186/s12978-015-0106-8

Reproductive Health

Table 3 Correlations between hormone levels and time stages of embryo development in women who achieved pregnancy and in women in whom pregnancy was not achieved

From: Ovarian stimulation with human and recombinant gonadotropin – comparison of in vitro fertilization efficiency with use of time-lapse monitoring

		tF	tC	t1	t2	t3	t4	t5	t6	t7	t8	t9	tM	tB
Group A (n = 77)
E2/f [pg/mL]	r	−0.157	0.026	−0.098	−0.038	0.096	−0.220	−0.146	−0.048	0.074	−0.043	−0.098	0.220	−0.035
E2/f [pg/mL]	p	0.172	0.823	0.395	0.744	0.406	0.055	0.206	0.676	0.522	0.710	0.397	0.055	0.760
FSH [mIU/mL]	r	−0.087	−0.150	0.024	0.088	−0.076	0.080	0.041	0.088	−0.066	0.005	0.117	0.043	0.251
FSH [mIU/mL]	p	0.454	0.194	0.837	0.446	0.512	0.492	0.726	0.446	0.570	0.965	0.310	0.710	0.028
AMH [ng/mL]	r	−0.118	−0.154	−0.085	−0.331	−0.111	−0.232	−0.119	−0.173	−0.093	0.142	−0.013	−0.019	−0.351
AMH [ng/mL]	p	0.306	0.180	0.460	0.003	0.336	0.042	0.301	0.133	0.422	0.219	0.912	0.871	0.002
Estradiol [pg/mL]	r	−0.085	−0.131	−0.193	−0.294	−0.169	−0.363	−0.292	−0.130	0.116	0.093	−0.043	0.056	−0.284
Estradiol [pg/mL]	p	0.464	0.258	0.093	0.010	0.141	0.001	0.010	0.259	0.316	0.419	0.709	0.626	0.012
LH [mIU/mL]	r	−0.024	−0.215	−0.102	0.084	−0.059	−0.076	−0.097	0.001	0.011	−0.247	0.270	0.103	0.117
LH [mIU/mL]	p	0.839	0.061	0.377	0.470	0.609	0.514	0.400	0.994	0.922	0.030	0.018	0.371	0.312
Group B (n = 144)
E2/f [pg/mL]	r	−0.034	−0.074	−0.121	0.017	−0.082	−0.151	−0.091	0.050	0.111	0.254	0.123	0.024	−0.086
E2/f [pg/mL]	p	0.685	0.376	0.149	0.844	0.330	0.071	0.281	0.551	0.185	0.002	0.143	0.774	0.305
FSH [mIU/mL]	r	0.078	−0.043	0.041	0.117	0.125	0.150	−0.143	0.150	0.017	−0.155	−0.046	0.131	0.281
FSH [mIU/mL]	p	0.352	0.611	0.627	0.164	0.134	0.073	0.087	0.074	0.837	0.064	0.584	0.118	0.001
AMH [ng/mL]	r	−0.107	−0.132	−0.197	−0.149	−0.221	−0.237	−0.051	−0.185	0.036	0.085	−0.080	−0.048	−0.279
AMH [ng/mL]	p	0.200	0.114	0.018	0.074	0.008	0.004	0.542	0.026	0.673	0.313	0.342	0.566	0.001
Estradiol [pg/mL]	r	−0.214	−0.100	−0.131	−0.072	−0.166	−0.225	−0.075	−0.142	0.074	0.068	−0.005	−0.015	−0.234
Estradiol [pg/mL]	p	0.010	0.232	0.118	0.393	0.047	0.007	0.370	0.091	0.379	0.417	0.953	0.863	0.005
LH [mIU/mL]	r	−0.190	−0.070	0.043	−0.047	0.077	0.062	0.040	0.001	−0.009	0.045	0.133	−0.085	0.068
LH [mIU/mL]	p	0.023	0.405	0.613	0.578	0.362	0.457	0.637	0.990	0.916	0.596	0.113	0.313	0.417

(r – Pearson’s correlation coefficient; p <0.05; Group A women who achieved pregnancy; Group B women in whom pregnancy was not achieved; E2/f estradiol per ≥17 mm follicle, FSH follicle-stimulating hormone, LH luteinizing hormone, AMH anti-Müllerian hormone, tF time of the first frame in which both pronuclei could be observed, tC the frame with the last observation of both pronuclei, t1-t9 times for corresponding numbers of cells, tM the first frame in which the embryos were compacting into the morula stage, tB the frame in which a crescent-shaped area began to emerge from the morula)

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