Table 1 Stillbirth rates during the pretrial (2010) and trial periods by ACT intervention group and site
From: The global network antenatal corticosteroids trial: impact on stillbirth
Pretrial period | ||||||||||||||||||
Argentina | Guatemala | Pakistan | Belgaum | Nagpur | Kenya | Zambia | Total | |||||||||||
Characteristica | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | RR (95 %)b | p-value |
All babies, N | 1,439 | 1,437 | 2,981 | 2,321 | 5,481 | 7,101 | 8,675 | 9,649 | 5,206 | 4,958 | 3,994 | 5,209 | 2,986 | 4,188 | 30,762 | 34,863 | ||
Stillbirths, N (Rate/1000)a | 28 (19.5) | 22 (15.3) | 67 (22.5) | 50 (21.5) | 295 (53.8) | 320 (45.1) | 255 (29.4) | 252 (26.1) | 148 (28.4) | 126 (25.4) | 84 (21.0) | 102 (19.6) | 101 (33.8) | 90 (21.5) | 978 (31.8) | 962 (27.6) | 1.17 (1.06,1.29) | 0.003 |
<5th percentile for weight babies, N | 81 | 99 | 124 | 123 | 717 | 746 | 358 | 389 | 267 | 299 | 167 | 217 | 176 | 214 | 1,890 | 2,087 | ||
<5th percentile stillbirths, N (Rate/1000)a | 16 (197.5) | 12 (121.2) | 27 (217.7) | 18 (146.3) | 214 (298.5) | 200 (268.1) | 150 (419.0) | 154 (395.9) | 90 (337.1) | 87 (291.0) | 36 (215.6) | 39 (179.7) | 54 (306.8) | 59 (275.7) | 587 (310.6) | 569 (272.6) | 1.15 (1.04, 1.28) | 0.008 |
Trial period | ||||||||||||||||||
Argentina | Guatemala | Pakistan | Belgaum | Nagpur | Kenya | Zambia | Total | |||||||||||
Characteristica | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | Int | Cntl | RR (95 %)b | p-value |
All babies, N | 2,122 | 2,311 | 5,863 | 3,978 | 7,800 | 8,315 | 15,022 | 16,774 | 7,570 | 7,655 | 5,993 | 7,187 | 4,328 | 5,787 | 48,698 | 52,007 | ||
Stillbirths, N (Rate/1000)a | 25 (11.8) | 31 (13.4) | 113 (19.3) | 73 (18.4) | 388 (49.7) | 351 (42.2) | 376 (25.0) | 382 (22.8) | 158 (20.9) | 181 (23.6) | 145 (24.2) | 154 (21.4) | 99 (22.9) | 92 (15.9) | 1,304 (26.8) | 1,264 (24.3) | 1.11 (1.02–1.22) | 0.018 |
Adjusted for pretrial SB rate 1.08 (0.99,1.17) | 0.073 | |||||||||||||||||
<5th percentile for weight babies, N | 105 | 149 | 390 | 192 | 984 | 890 | 777 | 874 | 464 | 377 | 288 | 252 | 260 | 263 | 3,268 | 2,997 | ||
<5th percentile stillbirths, N (Rate/1000)a | 14 (133.3) | 18 (120.8) | 44 (112.8) | 26 (135.4) | 224 (227.6) | 203 (228.1) | 244 (314.0) | 256 (292.9) | 107 (230.6) | 122 (323.6) | 53 (184.0) | 63 (250.0) | 62 (238.5) | 51 (193.9) | 748 (228.9) | 739 (246.6) | 0.99 (0.90–1.09) | 0.813 |
Adjusted for pretrial <5th percentile for weight SB rate 0.97 (0.89, 1.05) | 0.409 | |||||||||||||||||