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Table 2 Stillbirth characteristics by ACT intervention group

From: The global network antenatal corticosteroids trial: impact on stillbirth

  

RR (95 % CI)d

p-value

Characteristic a

Intervention

Control

Babies, N

48,698

52,007

--

--

Stillbirths (SB), N

1,304

1,264

--

--

Male SB rate, N (Rate/1000)

667 (26.6)

672 (25.0)

1.10 (0.99, 1.22)

0.086d

Female SB rate, N (Rate/1000)

561 (23.8)

540 (21.6)

1.08 (0.96, 1.22)

0.177d

Birth weight percentile b, N (% of stillbirths)

1,060

1,014

 

0.211e

  < 5th

601 (56.7)

612 (60.4)

  

 5–24

161 (15.2)

139 (13.7)

  

 25–49

110 (10.4)

102 (10.1)

  

 50–74

83 (7.8)

74 (7.3)

  

 75+

105 (9.9)

87 (8.6)

  

Birth weight categorizedc, N

1,259

1,218

  

  < 1000 g SB rate, N (Rate/1000)

161 (631.4)

197 (693.7)

0.93 (0.83, 1.05)

0.239d

 1000–1499 g SB rate, N (Rate/1000)

272 (443.0)

215 (378.5)

1.22 (1.10, 1.36)

0.0003d

 1500–2499 g SB rate, N (Rate/1000)

360 (51.6)

365 (57.4)

0.91 (0.78, 1.06)

0.218d

 2500+ g SB rate, N (Rate/1000)

466 (11.4)

441 (9.9)

1.18 (1.04, 1.33)

0.008d

Preterm SB rate, N (Rate/1000)

645 (116.6)

681 (127.8)

0.93 (0.83, 1.04)

0.182d

Term SB rate, N (Rate/1000)

535 (12.8)

477 (10.6)

1.20 (1.06,1.37)

0.004d

Macerated, N (% of stillbirths)

467 (35.8)

385 (30.5)

1.18 (1.04, 1.35)

0.013f

Women in the treatment group identified by the intervention as high risk who received steroids and delivered a stillborn baby

    

 Time since 1st dose to delivery, N (%)

271

  

  Less Than 2 Days

83 (30.6)

  

  2–7 Days

53 (19.6)

  

8–30 Days

61 (22.5)

  

  More than one month

74 (27.3)

  
  1. aStillbirth ≥ 20 weeks GA or ≥ 500 g. The denominator for the stillbirth rate is stillbirths + live births
  2. bSite-specific birth weight percentile (measured and estimated weights combined)
  3. cBirth weight groups (measured and estimated weights combined)
  4. dGeneralized linear models were used to evaluate the relationship between ACT intervention group and stillbirth and to develop point and interval estimates of relative risk (RR) associated with these risk factors. Generalized estimating equations were used to account for the correlation of outcomes within cluster to develop appropriate confidence intervals. Models were log binomial when possible, otherwise Poisson models were utilized. Models were adjusted for randomization strata
  5. eMantle Hansel chi-square test of ACT intervention group by birth weight percentile band adjusted for randomization strata
  6. fGeneralized linear model was used to evaluate the relationship between ACT intervention group and maceration among stillbirths and to develop point and interval estimates of relative risk (RR) associated with these risk factors. Generalized estimating equations were used to account for the correlation of outcomes within cluster to develop appropriate confidence intervals. Model was log binomial and was adjusted for randomization strata