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Table 2 Stillbirth characteristics by ACT intervention group

From: The global network antenatal corticosteroids trial: impact on stillbirth

   RR (95 % CI)d p-value
Characteristic a Intervention Control
Babies, N 48,698 52,007 -- --
Stillbirths (SB), N 1,304 1,264 -- --
Male SB rate, N (Rate/1000) 667 (26.6) 672 (25.0) 1.10 (0.99, 1.22) 0.086d
Female SB rate, N (Rate/1000) 561 (23.8) 540 (21.6) 1.08 (0.96, 1.22) 0.177d
Birth weight percentile b, N (% of stillbirths) 1,060 1,014   0.211e
  < 5th 601 (56.7) 612 (60.4)   
 5–24 161 (15.2) 139 (13.7)   
 25–49 110 (10.4) 102 (10.1)   
 50–74 83 (7.8) 74 (7.3)   
 75+ 105 (9.9) 87 (8.6)   
Birth weight categorizedc, N 1,259 1,218   
  < 1000 g SB rate, N (Rate/1000) 161 (631.4) 197 (693.7) 0.93 (0.83, 1.05) 0.239d
 1000–1499 g SB rate, N (Rate/1000) 272 (443.0) 215 (378.5) 1.22 (1.10, 1.36) 0.0003d
 1500–2499 g SB rate, N (Rate/1000) 360 (51.6) 365 (57.4) 0.91 (0.78, 1.06) 0.218d
 2500+ g SB rate, N (Rate/1000) 466 (11.4) 441 (9.9) 1.18 (1.04, 1.33) 0.008d
Preterm SB rate, N (Rate/1000) 645 (116.6) 681 (127.8) 0.93 (0.83, 1.04) 0.182d
Term SB rate, N (Rate/1000) 535 (12.8) 477 (10.6) 1.20 (1.06,1.37) 0.004d
Macerated, N (% of stillbirths) 467 (35.8) 385 (30.5) 1.18 (1.04, 1.35) 0.013f
Women in the treatment group identified by the intervention as high risk who received steroids and delivered a stillborn baby     
 Time since 1st dose to delivery, N (%) 271   
  Less Than 2 Days 83 (30.6)   
  2–7 Days 53 (19.6)   
8–30 Days 61 (22.5)   
  More than one month 74 (27.3)   
  1. aStillbirth ≥ 20 weeks GA or ≥ 500 g. The denominator for the stillbirth rate is stillbirths + live births
  2. bSite-specific birth weight percentile (measured and estimated weights combined)
  3. cBirth weight groups (measured and estimated weights combined)
  4. dGeneralized linear models were used to evaluate the relationship between ACT intervention group and stillbirth and to develop point and interval estimates of relative risk (RR) associated with these risk factors. Generalized estimating equations were used to account for the correlation of outcomes within cluster to develop appropriate confidence intervals. Models were log binomial when possible, otherwise Poisson models were utilized. Models were adjusted for randomization strata
  5. eMantle Hansel chi-square test of ACT intervention group by birth weight percentile band adjusted for randomization strata
  6. fGeneralized linear model was used to evaluate the relationship between ACT intervention group and maceration among stillbirths and to develop point and interval estimates of relative risk (RR) associated with these risk factors. Generalized estimating equations were used to account for the correlation of outcomes within cluster to develop appropriate confidence intervals. Model was log binomial and was adjusted for randomization strata