Table 1 Study outcomes

Clinical

Cardiovascular

Structure

Carotid artery intima-media thickness, retinal vessel photography

Function

Resting blood pressure, pulse wave velocity, augmentation index, carotid artery distensibility

Auxology

Height, weight, waist and hip circumference, bio-impedance

Respiratory function

Spirometry, plethysmography, multiple breath washout

Biomarkers

Cardiometabolic profile

Standard lipid profile and free fatty acids, fasting blood glucose, fasting blood insulin

Inflammatory plasma marker

High sensitivity C-reactive protein

Epigenetics

Genome-wide DNA methylation from blood derived at the time of birth (archival newborn screening cards) and at the time of the clinical assessment (adulthood). Gene expression from blood collected in adulthood.