From: Protected to death: systematic exclusion of pregnant women from Ebola virus disease trials
Location (Time) [Reference] | Number of pregnant women | Pregnancy stage | Age | Maternal outcome | Pregnancy outcome |
---|---|---|---|---|---|
A. Data available from previous epidemics to inform design of studies in the 2013–2016 EVD epidemic | |||||
Southern Sudan (1976) [69] | NS | NS | NS | NS | Occasional premature labour |
Zaire, Yambuku (1976) [18] | 82 | NS | NS | Died: 73/82 (89%) | Spontaneous abortion: |
18/73 who died | |||||
1/9 who survived | |||||
Live births to women who died: 11 (0 surviving beyond 19 days) | |||||
Zaire, Kikwit (1995) [17] | 15 | 1st: 4 (25%) | Mean: 32 | Died: 14/15 (93%) | Spontaneous abortion: |
2nd: 6 (40%) | Range: 24–38 | 9/14 who died | |||
3rd: 5 (33%) | 1/1 who survived | ||||
Stillbirth at 32 weeks: 1 | |||||
Full term live delivery: 1 (newborn died 3 days later, mother died due to extreme genital bleeding) | |||||
Gulu, Uganda [70] | 1 | 28 weeks | 30 | Discharged alive | Spontaneous abortion |
DRC, Isiro (2012) [71] | 1 | 7 months | 29 | Died one day after delivery | Premature delivery on day 6 of disease, newborn died at 8 days |
B. Data emerging during the 2013–2016 EVD epidemic | |||||
DRC, Equateur (July-Oct 2014) [47] | 1 | NS | NS | Died | Died in utero with mother |
Liberia, Monrovia (after August 2014)a [48] | 1 | Late stage | 31 | Died | Died in utero with mother |
Liberia, Monrovia (Aug - Oct 2014)a [53] | 4 | Late 2nd /3rd | NS | Died: 3 (75%) | Miscarriage shortly before maternal death: 3 |
Fetus carried to term: 0 | |||||
Guinea, Guéckédou (Feb/March 2014)b [50] | 1 | NS | 16 | Diedg | Spontaneous abortion |
Guinea, Guéckédou (June 2014)c [51] | 2 | 7 months | 20s | Survived | Stillbirths |
Guinea, Guéckédou (Dec 2014/Jan 15)c [52] | 2 | 4 months; 5 months | 40/22 | Survived | Miscarriages |
Guinea, Conakry (2015) [56] | 1 | 35–36 weeks | 25 | Died day of delivery (treated with favipiravir outside, but as per JIKI trial procedures) [38] | Live girl, EBOV qRT-PCR positive, monitored emergency use of ZMapp on days 2, 5, 8; buffy coat transfusion from EVD survivor on day 11 |
Sierra Leone, Kailahun (2014–2015)d [57] | 1 | 36 weeks | 34 | Survived | Induced delivery after diagnosis of intrauterine fetal death |
Sierra Leone, Kailahun, Kenema (May/June 2014) [55] | 1 | 35h | NS | Diedh | Miscarriage |
Sierra Leone, Bo (2014/2015)e [58] | 1 | 7 months | 20 | Survived | Stillborn fetus |
Guinea, Sierra Leone, Liberia MSF Ebola Treatment Centers (2014–2016) [56] | 54f | 2nd/3rd trimester | NS | NS | 2nd trimester miscarriages: 35 |
Neonatal death: 1 (after 2 days) | |||||
Guinea, Sierra Leone, Liberia MSF Ebola Treatment Centers (1 April 2014–15 April 2015)f [54] [49] | 77f [54] | 1st: 16 | 41/77 died: | Stillbirth: 30 | |
22 undelivered | Neonatal death: 1 | ||||
2nd: 26 | |||||
3rd: 28 | |||||
Missing information:7 | |||||
>20 | NS | 2 spontaneous abortions |