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Table 1 Published data on maternal and pregnancy outcomes after EBOV infection

From: Protected to death: systematic exclusion of pregnant women from Ebola virus disease trials

Location (Time) [Reference]

Number of pregnant women

Pregnancy stage

Age

Maternal outcome

Pregnancy outcome

A. Data available from previous epidemics to inform design of studies in the 2013–2016 EVD epidemic

 Southern Sudan (1976) [69]

NS

NS

NS

NS

Occasional premature labour

 Zaire, Yambuku (1976) [18]

82

NS

NS

Died: 73/82 (89%)

Spontaneous abortion:

 18/73 who died

 1/9 who survived

Live births to women who died: 11 (0 surviving beyond 19 days)

 Zaire, Kikwit (1995) [17]

15

1st: 4 (25%)

Mean: 32

Died: 14/15 (93%)

Spontaneous abortion:

2nd: 6 (40%)

Range: 24–38

 9/14 who died

3rd: 5 (33%)

 1/1 who survived

Stillbirth at 32 weeks: 1

Full term live delivery: 1 (newborn died 3 days later, mother died due to extreme genital bleeding)

 Gulu, Uganda [70]

1

28 weeks

30

Discharged alive

Spontaneous abortion

 DRC, Isiro (2012) [71]

1

7 months

29

Died one day after delivery

Premature delivery on day 6 of disease, newborn died at 8 days

B. Data emerging during the 2013–2016 EVD epidemic

 DRC, Equateur (July-Oct 2014) [47]

1

NS

NS

Died

Died in utero with mother

 Liberia, Monrovia (after August 2014)a [48]

1

Late stage

31

Died

Died in utero with mother

 Liberia, Monrovia (Aug - Oct 2014)a [53]

4

Late 2nd /3rd

NS

Died: 3 (75%)

Miscarriage shortly before maternal death: 3

Fetus carried to term: 0

 Guinea, Guéckédou (Feb/March 2014)b [50]

1

NS

16

Diedg

Spontaneous abortion

 Guinea, Guéckédou (June 2014)c [51]

2

7 months

20s

Survived

Stillbirths

 Guinea, Guéckédou (Dec 2014/Jan 15)c [52]

2

4 months; 5 months

40/22

Survived

Miscarriages

 Guinea, Conakry (2015) [56]

1

35–36 weeks

25

Died day of delivery (treated with favipiravir outside, but as per JIKI trial procedures) [38]

Live girl, EBOV qRT-PCR positive, monitored emergency use of ZMapp on days 2, 5, 8; buffy coat transfusion from EVD survivor on day 11

 Sierra Leone, Kailahun (2014–2015)d [57]

1

36 weeks

34

Survived

Induced delivery after diagnosis of intrauterine fetal death

 Sierra Leone, Kailahun, Kenema (May/June 2014) [55]

1

35h

NS

Diedh

Miscarriage

 Sierra Leone, Bo (2014/2015)e [58]

1

7 months

20

Survived

Stillborn fetus

 Guinea, Sierra Leone, Liberia MSF Ebola Treatment Centers (2014–2016) [56]

54f

2nd/3rd trimester

NS

NS

2nd trimester miscarriages: 35

Neonatal death: 1 (after 2 days)

 Guinea, Sierra Leone, Liberia MSF Ebola Treatment Centers (1 April 2014–15 April 2015)f [54] [49]

77f [54]

1st: 16

 

41/77 died:

Stillbirth: 30

 22 undelivered

Neonatal death: 1

2nd: 26

 18 delivered before death 36/77 survived [49] [54]

3rd: 28

Missing information:7

Guinea & Sierra Leone (April 2015–2016)i [43] [72]

>20

NS

  

2 spontaneous abortions

  1. DRC Democratic Republic of the Congo, formerly Zaire, NS not specified
  2. aELWA 3 MSF Ebola Treatment Unit, bMSF team, cMSF Ebola Teatment Centre Guéckédou, dMSF Ebola Treatment Unit Kailahun, eMSF Ebola Management Center Bo, fData on 77 women from eight MSF Ebola Management Centers includes 12 women in the 2nd and 3rd trimester reported in publications [48] [50] [51] [52] [53] [57]
  3. gSeverine Caluwaerts, personal communication: this woman is incorrectly reported in the publication as having survived
  4. hJ.S. Schieffelin, personal communication; outcome not reported in the paper [55]
  5. iA-M Henao-Restrepo and MSF, personal communication