Table 2 Summary of candidate predictors (Adapted from Barton and Sibai [35], Edwards 2015 [25], Albright et al. [36])

Maternal clinical findings

• Fever

• Temperature instability (core body temperature higher than 38.0 °C or lower than 36.0 °C)

• Tachycardia (heart rate greater than 110 beats/min)

• Tachypnoea (respiratory rate greater than 24 beats/min)

• O2 saturation, PaO2/FiO2

• Diaphoresis

• Nausea or vomiting

• Hypotension or shock

• Oliguria or anuria

• Pain (location based on site of infection)

• Altered mental state (confusion, decreased alertness, Glasgow Coma Scale score)

• Decrease capillarity refill, clammy or mottled skin

• Fetal distress (fetal tachycardia, acidosis)

Maternal Laboratory Findings

• Leucocytosis or leukopenia, immature neutrophils

• Positive culture from infection site or blood

• Hypoxemia

• Thrombocytopenia, INR, PTT

• Metabolic acidosis

• Hypoperfusion, increased serum lactate

• Low arterial pH

• Increased base deficit

• Elevated serum creatinine

• Elevated liver enzymes, bilirubin

• Serum urea

• Serum sodium

• Serum potassium

• Hyperglycaemia in the absence of diabetes

• Disseminated intravascular coagulation