Table 1 Types of information collected for preterm infants enrolled, neonatal deaths and stillbirths and for NICU admissions
All Enrolled Infants | Infant Deaths ≤ 28 days and Stillbirths | Infants admitted to NICU | |
|---|---|---|---|
General | • GA dating by LMP and US or Ballard examination • Obstetric history • Delivery information | • Autopsy • MITS: brain, liver, blood and lung tissue samples • X-ray • Placental pathology • Cord blood • Storage of samples for quality control • External physical examination • Photograph | • Complete blood count • CRP • Random blood sugar • Temperature • Head ultrasound when clinically indicated • Chest and abdominal x-ray when clinically indicated • Culture of blood, CSF and others when clinically indicated |
Infection study | • Maternal GBS swab on hospital admission • Maternal syphilis screening test • Maternal serum for antibody analysis | • Placental tissue (PCR) • Liver, lung and brain tissue (PCR) • Cord and/or heart blood (PCR) For all deaths, we will collect several fetal/infant dried blood spot cards (DBS) to be used for organism confirmation if necessary | |
Hemoglobin, metabolic and genetic disorders | Testing for cause of death using DBS, blood and tissue DNA, if indicated based on screening criteria |