Distribution of postpartum blood loss: modeling, estimation and application to clinical trials

Table 3 Estimated proportions of sPPH for the four trials, with two-sided 95% confidence intervals (CI), by the binomial and by the lognormal approaches: Misoprostol trial [17], Active Management trial [19], CHAMPION trial [18] and Althabe et al. trial [20]

Trial	Treatment	Proportion	95% CI		Width of the 95%CI	Width ratio lognormal vs binomial (%)
Trial	Treatment	Proportion	Lower limit	Upper limit	Width of the 95%CI	Width ratio lognormal vs binomial (%)
Binomial
Misoprostol	Misoprostol	0.03962	0.03582	0.04380	0.00797	–
Misoprostol	Oxytocin	0.02839	0.02520	0.03199	0.00679	–
Active Management	Simplified Package	0.02057	0.01814	0.02331	0.00517	–
Active Management	Full Package	0.01885	0.01653	0.02148	0.00495	–
CHAMPION	Aggregated	0.01560	0.01400	0.01739	0.00339	–
Althabe et al	Hands Off	0.05102	0.02199	0.11392	0.09194	–
Althabe et al	CCT	0.02970	0.01015	0.08372	0.07356	–
Lognormal
Misoprostol	Misoprostol	0.02976	0.02740	0.03229	0.00490	61.4
Misoprostol	Oxytocin	0.01748	0.01582	0.01928	0.00346	51.0
Active Management	Simplified Package	0.01760	0.01603	0.01930	0.00327	63.2
Active Management	Full Package	0.01685	0.01532	0.01850	0.00317	64.0
CHAMPION	Aggregated	0.01737	0.01617	0.01865	0.00248	73.2
Althabe et al	Hands Off	0.03799	0.01655	0.07807	0.06151	66.9
Althabe et al	CCT	0.03250	0.01369	0.06885	0.05515	75.0

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