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Table 4 Estimated proportions of PPH for the four trials, with two-sided 95% confidence intervals (CI), by the binomial and by the lognormal approaches: Misoprostol trial [17], Active Management trial [19], CHAMPION trial [18] and Althabe et al. trial [20]

From: Distribution of postpartum blood loss: modeling, estimation and application to clinical trials

Trial

Treatment

Proportion

95% CI

Width of the 95%CI

Width ratio lognormal vs binomial (%)

Lower limit

Upper limit

Binomial

 Misoprostol

Misoprostol

0.19462

0.18666

0.20283

0.01617

Oxytocin

0.13526

0.12843

0.14239

0.01396

 Active Management

Simplified Package

0.13751

0.13137

0.14389

0.01252

Full Package

0.12847

0.12251

0.13468

0.01217

 CHAMPION

Aggregated

0.09128

0.08743

0.09530

0.00787

 Althabe et al

Hands Off

0.22449

0.15318

0.31658

0.16340

CCT

0.16832

0.10783

0.25311

0.14528

Lognormal

 Misoprostol

Misoprostol

0.17866

0.17236

0.18510

0.01275

78.8

Oxytocin

0.13030

0.12481

0.13596

0.01115

79.9

 Active Management

Simplified Package

0.14198

0.13687

0.14722

0.01035

82.7

Full Package

0.13192

0.12697

0.13701

0.01004

82.5

 CHAMPION

Aggregated

0.09709

0.09381

0.10046

0.00665

84.5

 Althabe et al

Hands Off

0.23344

0.17098

0.30684

0.13586

83.1

CCT

0.18662

0.13103

0.25485

0.12382

85.2