From: Distribution of postpartum blood loss: modeling, estimation and application to clinical trials
Event Approach | Trial | RR | 95% CI | Width of the 95% CI | Width ratio lognormal vs binomial (%) | |
---|---|---|---|---|---|---|
Lower limit | Upper limit | |||||
sPPH | ||||||
Binomial | Misoprostol | 1.39 | 1.19 | 1.63 | 0.44 | – |
Active Management | 1.09 | 0.91 | 1.31 | 0.40 | – | |
CHAMPION | 1.04 | 0.87 | 1.25 | 0.38 | – | |
Althabe et al | 1.76 | 0.40 | 7.56 | 7.16 | – | |
Lognormal | Misoprostol | 1.69 | 1.48 | 1.92 | 0.44 | 100.0 |
Active Management | 1.05 | 0.91 | 1.20 | 0.29 | 72.5 | |
CHAMPION | 1.00 | 0.89 | 1.13 | 0.24 | 63.2 | |
Althabe et al | 1.16 | 0.38 | 4.44 | 4.06 | 56.7 | |
PPH | ||||||
Binomial | Misoprostol | 1.44 | 1.35 | 1.54 | 0.19 | – |
Active Management | 1.07 | 1.00 | 1.14 | 0.14 | – | |
CHAMPION | 0.99 | 0.92 | 1.06 | 0.14 | – | |
Althabe et al | 1.33 | 0.76 | 2.35 | 1.59 | – | |
Lognormal | Misoprostol | 1.37 | 1.29 | 1.45 | 0.16 | 84.2 |
Active Management | 1.08 | 1.02 | 1.14 | 0.12 | 85.7 | |
CHAMPION | 1.01 | 0.95 | 1.06 | 0.11 | 78.6 | |
Althabe et al | 1.26 | 0.81 | 1.95 | 1.14 | 71.7 |