Cost of goods sold analysis and recommendations to reduce costs of co-packaged mifepristone–misoprostol for medical abortion

Table 1 Misoprostol and mifepristone formulations

Misoprostol	Measurement^a	Per tablet	Per combi-pack
Misoprostol solid dispersion (1% in HPMC)	mg	20.20	80.80
Microcrystalline cellulose	mg	172.10	688.50
Sodium starch glycolate	mg	6.30	25.20
Hydrogenated castor oil	mg	1.40	5.60
Mifepristone
Mifepristone	mg	200.00	200.00
Magnesium stearate	mg	3.75	3.75
Corn starch	mg	75.75	75.75
Microcrystalline cellulose	mg	60.00	60.00
Povidone	mg	14.50	14.50
Silica colloidal anhydrous	mg	6.75	6.75

^a The API procured for most part of the manufacturers is a dispersion of 1% misoprostol in hydroxypropyl methyl cellulose (HPMC). For this reason, the weight of the API introduced into the process is proportionally adjusted to ensure that each tablet will contain 0.2 mg of Misoprostol. The weight of the misoprostol component (1% misoprostol in HPMC) is therefore 20.2 mg per tablet, however it contains 0.2 mg of misoprostol

ISSN: 1742-4755