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Table 1 Described consequences of Perinatal Cannabis Exposure in Humans and Rodents

From: Cannabis use during pregnancy and its relationship with fetal developmental outcomes and psychiatric disorders. A systematic review

 HumansRodents
System- alterations on the mesocorticolimbic system [15, 16].
- thicker prefrontal cortex [43].
- changes in the dopaminergic activity of the corpus striatum and on the prefrontal cortex [21].
- dopaminergic activity of the hypothalamic–pituitary axis and the amygdala [13].
- alterations in the cortical glutamatergic system and affects the migration of glutamatergic neurons and GABAergic interneurons [22, 23].
- alterations in the intrinsic electrophysiological properties of the Purkinje neurons of the cerebellum [24].
Molecular- high CB1 mRNA expression in the fetal hippocampus and amygdala [15].
- decrease in the expression of proenkephalin mRNA in the fetal striatum with a dose-dependent effect [20, 47].
- up-regulation of proenkephalin mRNA in the mesolimbic area in adult life [20, 47].
- increased expression of u-opioids in the amygdala [17,18,19,20, 47].
- decrease of k-opioid receptor mRNA in the mid-dorsal thalamus [17,18,19,20, 47].