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Table 3 Outcomes following induction of labor according to the route of administration of misoprostol

From: Misoprostol administered sublingually at a dose of 12.5 μg versus vaginally at a dose of 25 μg for the induction of full-term labor: a randomized controlled trial

Endpoints

Sublingual misoprostol (n = 98)

Vaginal misoprostol (n = 100)

RR

95% CI

p-value

n

%

n

%

Tachysystole (> 6 contractions in 10 min)

1

1

12

12

0.15

0.02–0.97

0.002**

Change in cervix after 12 h

58

59.2

52

52.0

1.16

0.87–1.55

0.31**

Change in cervix after 24 h

73

74.5

74

74.0

1.01

0.73–1.40

0.94**

Failure to achieve vaginal delivery within 12 h

90

91.8

93

93.0

0.92

0.56–1.51

0.76**

Failure to achieve vaginal delivery within 24 h

70

71.4

66

66.0

1.14

0.83–1.57

0.41**

Need for oxytocin

33

33.7

24

24.0

1.25

0.94–1.67

0.13**

Epidural anesthesia

2

2.0

1

1.0

1.35

0.60–3.05

0.98*

Maternal preference for sublingual route

65

66.3

54

54.0

1.31

0.96–1.78

0.08**

Nausea

5

5.1

9

9.0

0.71

0.34–1.45

0.28**

Vomiting

2

2.0

2

2.0

1.01

0.37–2.72

1.00*

Diarrhea

1

1.0

2

2.0

0.67

0.13–3.34

1.00*

Caesarean section

56

57.1

56

56.0

1.02

0.77–1.36

0.87**

Meconium

6

6.1

11

11.0

0.69

0.36–1.34

0.22**

Admission to neonatal intensive care unit

1

1.0

1

1.0

1.01

0.25–4.07

1.00*

Neonatal resuscitation

4

4.1

2

2.0

1.36

0.76–2.44

0.66*

  1. CI Confidence interval. * Fisher’s exact test, ** Chi-square test, RR: relative risk