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Table 4 Multivariable logistic regression analysis predicting risk factors for infertility

From: Incidence and risk factors of infertility among couples who desire a first and second child in Shanghai, China: a facility-based prospective cohort study

 

All couples

First child

Second child

AOR [95% CI]

P value

AOR [95% CI]

P value

AOR [95% CI]

P value

Age, years, women

 20–24

Reference

0.008

Reference

< 0.001

Reference

0.040

 25–29

1.41 [0.64, 3.09]

1.23 [0.67, 2.12]

1.02 [0.57, 1.86]

 30–34

1.96 [0.89, 4.32]

1.54 [0.87, 3.01]

0.97 [0.45, 1.34]

 35–39

2.09 [0.88, 4.96]

1.70 [1.27, 2.28]

0.55 [0.13, 2.46]

 ≥ 40

5.93 [1.79, 19.67]

7.89 [2.41, 25.79]

7.36 [1.01, 53.84]

BMI, kg/m2, women

 < 18.5

1.20 [0.78, 1.84]

0.017

1.06 [0.68, 1.64]

0.017

1.46 [0.14, 15.70]

0.894

 18.5–23.9

Reference

Reference

Reference

 24–27.9

1.39 [0.90, 2.13]

1.58 [1.01, 2.45]

0.52 [0.05, 5.82]

 ≥ 28

2.73 [1.40, 5.32]

2.86 [1.31, 6.26]

NA

BMI, kg/m2, men

 < 18.5

3.41 [1.51, 7.71]

0.033

3.09 [1.42, 6.74]

0.017

NA

0.965

 18.5–23.9

Reference

Reference

Reference

 24–27.9

1.11 [0.81, 1.52]

1.37 [0.99, 1.90]

1.47 [0.35, 6.23]

 ≥ 28

1.07 [0.70, 1.65]

1.26 [0.82, 1.94]

NA

Menstrual duration, days

 < 2

NA

0.035

NA

< 0.001

NA

 

 2–7

Reference

Reference

Reference

0.998

 > 7

2.34 [1.23, 4.45]

4.47 [2.25, 8.88]

0.99 [0.10, 9.89]

 

Leiomyoma

 No

Reference

0.013

Reference

0.119

Reference

0.043

 Yes

1.66 [1.11, 2.46]

1.38 [0.92, 2.07]

5.60 [1.06, 29.76]

Endometrial polyp

 No

Reference

< 0.001

Reference

< 0.001

Reference

0.578

 Yes

2.87 [1.67, 4.94]

2.52 [1.28, 4.97]

1.99 [0.18, 22.32]

PCOS

 No

Reference

< 0.001

Reference

< 0.001

NA

 Yes

3.89 [2.28, 6.64]

6.72 [1.79,7.39]

NA

Endometriosis

 No

Reference

< 0.001

Reference

0.001

NA

 Yes

3.65 [1.92, 6.95]

2.52 [1.27, 4.97]

NA

Salpingostomy

 No

Reference

< 0.001

Reference

< 0.001

Reference

0.130

 Yes

4.04 [2.04, 7.98]

3.44 [1.68, 7.07]

9.28 [0.52, 166.22]

Chlamydia genitalium, women

 No

Reference

0.024

Reference

0.015

Reference

0.587

 Yes

1.96 [1.09, 3.52]

1.54 [1.09, 2.40]

0.53 [0.05, 5.20]

  1. BMI body mass index, PCOS polycystic ovarian syndrome, AOR adjusted odds ratio, CI confidence interval
  2. Nagelkerke R2 = 0.622