Fig. 2
From: A novel homozygous mutation in the PADI6 gene causes early embryo arrest
Identification of PADI6 mutation in one affected family. a Pedigree of a family who carry the PADI6 mutation. The affected individual shows homozygous mutation. Squares indicate male individuals, and circles indicate female individuals. The black circle with an arrow indicates the affected individual, and blank symbols indicate unaffected individuals. The equal sign represents infertility. b Sanger sequencing confirmation of the proband and control. c Homozygosity mapping of the proband. Homozygous regions harboring the strongest signal are indicated in red, and the asterisk (*) denotes where PADI6 is located