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Table 4 General analysis of the prevalence of anencephaly per 10,000 births worldwide and continents by sample size, heterogeneity, publication bias

From: Global prevalence of congenital anencephaly: a comprehensive systematic review and meta-analysis

Meta-analysis

N

Sample size

I2

Begg and Mazumdar

Prevalence (95% CI)

Overall prevalence

340

169,407,738

99.9

0.105

5.1 (95% CI 4.7–5.5)

Continent

 Asia

50

12,449,402

99.9

0.776

6.5 (95% CI 5.5–7.7)

 Europe

126

43,826,079

99.9

0.906

4.8 (95% CI 4.2–5.5)

 America

128

106,111,868

99.9

0.809

4.3 (95% CI 3.8–4.8)

 Africa

5

4,415,752

99.9

0.278

6.5 (95% CI 1–9.9)

 Australia

30

12,615,064

99.7

0.111

8.6 (95% CI 7.7–9.5)