Table 2 AYA cancer and risk of premature ovarian insufficiency in Ontario, Canada
Type of cancer | Age at cancer diagnosis | Age at POI diagnosis | POI Rate | Unadjusted | Adjusteda |
|---|---|---|---|---|---|
| Â | Mean (SD) | Mean (SD) | n (%) | RR (95% CI) | RR (95% CI) |
Unexposed | – | – | 2434 (2.2) | – | – |
All | 32.1 (6.0) | 34.8 (4.4) | 1160 (5.4) | 2.51 (2.33, 2.70) | 2.49 (2.32, 2.67) |
Breast cancer | 35.1 (3.8) | 36.5 (2.7) | 502 (7.1) | 4.41 (3.91, 4.96) | 4.32 (3.84, 4.86) |
Leukemia | 29.2 (7.4) | 31.7 (5.3) | 123 (21.0) | 14.50 (10.42, 20.18) | 14.64 (10.50, 20.42) |
Hodgkin lymphoma | 26.0 (6.7) | 31.4 (5.6) | 124 (7.5) | 2.38 (1.92, 2.97) | 2.37 (1.91, 2.96) |
Non-Hodgkin lymphoma | 30.9 (6.5) | 35.1 (4.0) | 95 (7.5) | 3.91 (2.97, 5.16) | 3.77 (2.88, 4.94) |
Thyroid cancer | 31.5 (5.9) | 34.9 (4.3) | 232 (2.8) | 1.26 (1.09, 1.47) | 1.26 (1.09, 1.46) |
Melanoma | 31.4 (5.8) | 34.6 (4.2) | 84 (2.8) | 1.04 (0.82, 1.33) | 1.04 (0.82, 1.32) |