Motherhood and decision-making among women living with HIV in developed countries: a systematic review with qualitative research synthesis

Background Women living with HIV (WLH) lack evidence-based information about reproductive options while managing pressures from family, clinicians, and communities to give up the idea of having children. As the reproduction intentions of WLH are not well understood, stigmatizing behaviors force them to hide their disease to avoid rejection by their family, partner, and social networks. Compliance with social norms, fear of stigma, and discrimination influence their experience. Current research is individual qualitative studies lacking the synthesis perspective necessary to guide intervention development. The purpose of this study was to synthesize the evidence to explain the reproductive decision-making process for WLH in developed countries. Methods A systematic review with qualitative research synthesis was conducted through searches in 10 electronic databases (CINAHL, EMBASE, MEDLINE, Scopus, Social Science Citation Index, Web of Science, Google Scholar, Cuidatge, Cuiden Enfispo, and SciELO). Studies published in journals from 1995 to 2019 with qualitative data about reproductive decision-making among WLH in developed countries were eligible for inclusion. Developed country was operationalized by membership in the OECD for comparative conditions of social wellbeing and economic stability. The CASP and JBI checklists for qualitative research were used to assess study quality and methodological integrity. Thematic analysis and qualitative meta-summary techniques were used for the synthesis. Results Twenty studies from 12 developed countries were included in the synthesis. Findings were organized into 3 meta-themes from 15 themes and 45 subthemes, including: (1) Shattered identity, (2) Barriers, inequities, and misinformation, (3) Coping, resiliency, and support. Reproductive decision-making was perceived as a complex process influenced by facilitators and barriers. The facilitators helped WLH cope with their new situation to become more resilient, while the barriers made their situation more difficult to manage. Conclusion WLH encounter reproductive decision-making with knowledge deficits and limited social support. An integrated approach to holistic care with comprehensive multidisciplinary counseling is needed to support WLH. Clinicians could benefit from professional development to learn how to be authentically present for WLH, including engaging in conversations, demonstrating compassion, and understanding situations. Evidence-based clinical practice guidelines need to be tailored for the family planning and sexual health needs of WLH.


Plain Language Summary
Women living with HIV can become pregnant and deliver a healthy baby due to advances in medicine. Being a mother is an important role that gives meaning to life for most women. For women living with HIV thinking about having a baby is difficult because HIV complicates many areas of daily living. When women living with HIV try to speak with physicians and nurses about having a baby, they often do not feel supported and report feeling stigmatized. This review of the scientific literature summarizes the experiences of women living with HIV in developed countries as

Introduction
Globally there are nearly 40 million people living with HIV, more than half are women [1]. In 2018, 82% of pregnant women living with HIV (WLH) had access to antiretroviral treatment to prevent mother-to-child transmission, with higher rates in developed countries [2]. The wider treatment coverage and improved adherence among WLH has rapidly reduced AIDS-related deaths among women [3]. Increased access to highly active anti-retroviral therapy (HAART) shifted HIV from an acute illness to a chronic disease [4] for women in terms of life expectancy, quality of life, and the opportunity for motherhood [5][6][7] Motherhood is an important role that gives meaning to life for many women; however, decisions about pregnancy and childbearing are often complex as HIV impacts many aspects of daily living [8]. The factors influencing reproductive decision-making include concerns about the baby being born with HIV and the longevity of life for the mother [9,10]. Pregnancy with HIV brings increased risk for complications [5,8] including maternal infection and adverse perinatal outcomes [9,11,12]. Following the introduction of HAART, however, motherto-child transmission was reduced to less than 1% in developed countries [13]. The knowledge transfer of this evidence into clinical practice, within communities, and throughout the general public has been slow [14].
Although cesarean section was the recommended mode for delivery prior to HAART [15,16] European guidelines now promote vaginal delivery [17] as maternal viral load was identified as the most significant risk factor for perinatal HIV infection. Despite favorable conditions for a minimal risk pregnancy in developed countries, researchers suggest HIV serostatus and knowledge about HIV transmission does not significantly influence reproductive decision-making for WLH [18,19]. Due to the available conception and contraception options, WLH can avoid pregnancy or safely attempt pregnancy with good outcomes [20]. Yet, only a third of WLH in developed countries reported a pregnancy since their diagnosis [11]. Despite significant advancements in medical technology and improvements in clinical practice, reproductive decision-making continues to be guided by historical perspectives and outdated evidence.

Rational for review
WLH lack evidence-based information about reproductive options while managing pressures from family, clinicians, and communities to give up the idea of having children [19,21]. Since reproduction intentions of WLH are not well understood [22], stigmatizing behaviors force women to hide their disease in order to avoid rejection by their family, partner, and social networks [8]. Compliance with social norms, fear of stigma, and discrimination influence their experiences and guide their behaviors [23] Misinformation and prejudice continue in clinical practice [24] as WLH do not feel supported by their clinicians. They report discrimination and stigma in some cases [25]; with the resulting fear and anxiety negatively impacting their relationships with clinicians and their confidence in the health system [26]. WLH require comprehensive evidence-based care to safely fulfill their decisions about motherhood, whether this involves preventing [9] or safely advancing a pregnancy [27].
Developed countries provide WLH with the most supportive environments for sexual health and to engage in reproductive decision-making. As such, the purpose of this study was to explain the reproductive decision-making process of WLH in developed countries according to their lived experiences through a synthesis of the qualitative literature. The study fills an important gap in the literature as the research is individual qualitative studies lacking the synthesis perspective necessary to guide intervention development [14,53].

Methods
Qualitative research synthesis (QRS) [54], or the aggregative approach to synthesis [55], is aligned with the philosophy of pragmatism where "meanings exist as ready-made" [56] to convey "practical usefulness" [57] that informs decisions and practices at the clinical or policy levels [58]. As such, the result of a QRS is more than a simple summary of findings from the literature [59]. For this reason, we completed a QRS with a multinational team approach [60] to interpret data from systematically selected articles to generate new insights and additional knowledge [61]. The research protocol (CRD42018091971) was registered with the International Prospective Register of Systematic Reviews, PROSPERO [62]. The results are reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [63], and the Enhancing Transparency in Reporting the synthesis of Qualitative research (ENTREQ) recommendation [64].

Inclusion criteria
Studies published in peer-reviewed journals between January 1995 (the year HAART appeared) and December 2019 using qualitative methods to address reproductive decision-making in WLH were included in this study. The term 'developed country' was operationalized by membership in the Organization for Economic Co-operation and Development (OECD). In this regard, the 35 OECD [65] member countries are substantially similar in their compliance with international laws, adherence to human rights conventions, and adoption of evidence-based clinical practice guidelines for HIV/AIDS [66][67][68][69]. The publication language was limited to English, French, German, Portuguese, and Spanish as these were the language proficiencies of the research team. Studies were excluded if the target population was women less than 18 years or more than 50 years of age, women living in prisons or psychiatric institutions, or mixed-method studies or systematic reviews in which qualitative data could not be separated from the quantitative.

Search strategy
Multiple electronic databases were searched including CINAHL, EMBASE, MEDLINE (through PubMed), Scopus, Social Science Citation Index, Web of Science, Google Scholar, and the Spanish databases Cuidatge, Cuiden Enfispo, and SciELO from January 1995 to December 2019. Although most qualitative research articles for this review were anticipated to be indexed in the MEDLINE database [70], all research articles related to reproductive decision-making and WLH were of interest. As such, the database filters specific to research methods were not used to limit the possibility for bias in article selection [71]. To minimize unintended bias in the search strategy, published recommendations were referenced for searching databases, including CINAHL [72], EMBASE [73], MEDLINE [74] and PsycINFO [75].
Keywords, defined by the research team and informed by systematic reviews in related areas, were joined by Boolean operators for the database searches. Keywords were used to avoid problems with the unique thesaurus terms for each database with varied meanings between disciplines [73,76]. The keywords included: HIV, AIDS, human immunodeficiency virus, acquired immunodeficiency syndrome, women, women living with HIV, childbearing, desire for children, fertility, family planning, pregnancy, reproduction, reproductive behavior, reproductive choice, reproductive health, decisions, decision making, intention, and mother-to-child transmission.
The search strategies were tested in November 2017. An example of the algorithm used for the PubMed search strategy is provided in Table 1. The full searches were completed the week of December 17, 2018 with an updated search for the calendar year 2019 completed in June 2020. This systematic review serves as the foundation for a living systematic review [77] with updates scheduled every five years.

Study screening
The study screening was completed with a structured process [78]; first by title review, then by abstract review, and finally by full text review by four pairs of experienced reviewers. The study titles were first independently screened by paired reviewers to identify the studies that met the inclusion criteria. Next, the reviewers evaluated the abstracts for inclusion, reviewing a different group than the previous step. Finally, the reviewers assessed the full text of the remaining articles by strictly applying the inclusion and exclusion criteria. During each round, a third reviewer checked the work of each review pair for errors. If there was disagreement between the paired reviewers, the document advanced to the next review process to limit deselection bias. The primary investigator checked the level of agreement between review pairs for the title and abstract phases, with the goal of 95% agreement. During the full text review, the excluded and included articles were checked by another pair of reviewers as a final verification. At this point, six studies were excluded from the synthesis due to samples with all men (n = 3), serodiscordant couples with HIV negative women (n = 2), and no participants due to a descriptive rather than research-based article (n = 1). The PRISMA diagram provides an overview of the screening process (see Fig. 1).

Quality assessment
The research team included the appropriate methods and content experts [79] to develop a clear, justified, and focused review question [80] with realistically defined objectives [81] for an expansive search strategy to identify relevant research [82]. Four pairs of reviewers independently screened the articles by applying the inclusion criteria and assessing the risk of bias. Discrepancies were solved by AHZ and JLM; and then reviewed by an external researcher. Each article included in the full text analysis was peer-reviewed (AHZ and JLM), and independently assessed (AHZ, JLM, and PAP) for methodological criteria with the 10-item Critical Appraisal Skills Programme (CASP) qualitative checklist [83]. Consensus was required for inclusion of an article. Congruence between theory, methods, and analysis, researcher reflexivity, and ethical protections was also assessed with the JBI Critical Appraisal Checklist for Qualitative Research Studies [55]. The checklists were applied to assess the minimum quality of study methods, adequacy of ethical protections, and trustworthiness [84] rather than to exclude interview data from papers as this could introduce bias [85]

Data extraction
The primary focus for the data extraction was the results and the conclusions sections of each article. General data extracted from the articles, line-by-line, were assembled in an Excel spreadsheet, including study setting, aim, participants, study design, direct quotes, and key findings. Then, the data were imported into Nvivo ® to digitally record the codes that emerged as themes from the coding [86]. The level of coding was words, phrases, and sentences.

Data synthesis
Following the recommendations of Sandelowski and Barroso [54], the data analysis was circular rather than linear to facilitate movement between the emergent themes from the findings [87]. This process resulted in a taxonomy of findings from sustained comparisons, concepts translated in vivo, and imported concepts [88]. The taxonomy was comprised of items with different semantic relations, either within the same or between different themes.
In a staged process [89], two researchers (AHZ and JLM) conducted an inductive analysis [90] followed by a deductive process. The results were discussed and triangulated with two other researchers (JEE and SKC) and checked by additional researchers (PAP and KDC). The relationships, similarities, and dissonances were synthesized across studies. During this process, key concepts and conceptual themes were identified. Relevant findings from one study were compared to the themes, metaphors, and concepts in the other studies. As recommended by King [91], the thematic analysis was not finalized until all the data were reviewed and the codes checked multiple times.

Trustworthiness
The protocol for this QRS was designed to maximize descriptive validity (factual accuracy of data), interpretive validity (validity referred to in descriptions of member checking), theoretical validity (credibility of researcher interpretations), and pragmatic validity (utility and transferability of knowledge) [87,92,93]. In this regard, several techniques were incorporated into the protocol such as the check and rechecks of the initial search results, maintenance of an audit trail, multiple researchers completing article appraisals, expert peer reviews, team 'huddles' to discuss individual and comparative appraisals, member checks, and ongoing discussion and negotiation [94][95][96][97].

Ethics
Ethics approval was not necessary as the searches were conducted in public databases. There were no human subjects involved in this study. However, the included studies were evaluated for ethical standards with the JBI Checklist. Each of these studies was approved by an ethics committee or institutional review board.

Results
A total of 4,519 articles were identified through the systematic literature searches and reduced to a sample of 20 qualitative articles for analysis (see Table 2). Each article met the requirement for inclusion using the CASP checklist. However, one article [98] was assessed as weak in theoretical and methodological congruence with the JBI checklist but included to limit selection bias. The articles represented 1,395 participants with data from 12 of the 35 OECD member countries; about half the studies were from urban areas within the United States.
From the data, 45 subthemes emerged, and these were organized into 15 themes. Then, the themes were grouped into three meta-themes to explain the factors influencing the reproductive decision-making of WLH, including: (1) Shattered identity, (2) Barriers, inequities, and misinformation, (3) Coping, resiliency, and support (see Table 3). When women learned about their HIV positive diagnosis, their meaning in life changed, and their identity altered. Yet, motherhood remained a primary goal for the women. Reproductive decision-making was perceived as a complex process influenced by many facilitators and limited by as more barriers. The facilitators helped WLH cope with their new situation to become more resilient, while the barriers made their situation more difficult to manage.

Shattered identity
WLH described a shattered identity, referring to two main areas: their womanhood and their motherhood experiences. When they learned of their positive status, they were devastated, and they no longer felt like a woman [61,99]. They described how HIV assaulted their bodies; stole their sense of beauty, and left the perception of dirtiness [61]. HIV was a barrier present everywhere and all the time [61,[98][99][100] "Ah, it's just always in the bedroom, HIV. It's always there. " [98] "…when I looked at myself in the mirror, I could see around me the shadow of the virus (...). It was horrible because I was disgusted by myself. I looked at myself in the mirror and I could see around me, literally, a grey shadow ... And I thought "this is the virus. " [100] Sexual and reproductive decisions were modified; their desire for intimacy reduced, sexual life changed, and breastfeeding prohibited [101]. They feared disclosing their HIV status to intimate partners, family, and friends as they lost their sense of normality [61]. Their life plans were broken when HIV unexpectedly appeared [61,102]. Their identity was subjected to continued self-criticism that required interventions to redefine themselves. However, pregnancy was perceived to be a route to being normal and a way to feeling complete as a woman [61,101,103] "It [pregnancy] is sort of like a completion of myself as a woman. " [103] Motherhood was one of the most important social identities for women. WLH felt recognized by their community when had a child [104,105] because motherhood is a cultural norm. The phenomenon was therefore culturally constructed [8,104,106]   "I just want one. I don't want a whole house full… I just want one baby, something that's me, a part of me. That's something that I can develop and it's still great too. " [106] Some WLH felt pushed by their families and others to become mothers [107]. Many women reported losing their children to adoption, foster care, or placement with family members due to acute illnesses, chronic diseases, and/or criminal problems such as drug abuse. These broken mothering opportunities resulted in intense guilt and emotional pain. Consequently, WLH were psychologically harmed and their identity often permanently damaged [19,108].

Barriers, inequities, and misinformation Institutions and clinicians
When making reproductive decisions, WLH encountered barriers to accessing health services [106], including difficulty obtaining appointments, lengthy wait times at appointments, problems with insurance coverage, inadequate transportation, and issues related to immigration status. These barriers resulted in some women accessing services at new clinics with unfamiliar clinicians that resulted in uncomfortable feelings [106].  [106] WLH generally felt clinicians were not supportive, reporting HIV-related stigma [19,61,101,102,106,109,110]. The WLH felt their physicians were not helpful and explained they tried to discourage them from pregnancy due to their HIV positive status [105,110].
"My doctor was really insensitive […]. I really felt trapped. " [110] The physicians never asked about their desire to have children [105]. As a result they felt repressed, as their right to decide was coerced [107,109].
"The people had pretty much brainwashed me . . . they just reared into me, telling me . . . "Right now it's not a good time . . ., you ain't got a place to live, you ain't got no food, you ain't got no job, you ain't got this, you ain't got that. " So, I took a look at all that and just decided to have an abortion … [I]t hurt, you know, because I wanted to keep it but I had to take a look at the situation and say, oh okay, that, that was right, yeah, okay. That's true, though, but let me make that decision, you know, it was just like a rushed thing and . . . and I said okay, I'll have an abortion, I can't do anything else." [109] WLH wanted more information about contraception methods and approaches to safe sex. They wanted to learn about their disease, including more discussions with clinicians; something they were unable to find in the health system [61,105,107,111].
"I look for things that are safe 100%. There have not been recorded cases of anyone becoming infected (in oral sex), so I thought that's 100% safe. So like a month later I was reading another one of these small leaflets and it says although the risk is small there is some risk and I started to become a bit paranoid. " [111]

Misinformation and fears
Their general knowledge about HIV, varied; however. WLH commonly believed they cannot be mothers. They had the wrong beliefs about the impact of HIV on their ability to become pregnant [99,105,106].
"Like most women, I always wanted to have a baby, but thought it wasn't an option anymore when I was diagnosed with HIV." [105] In terms of becoming pregnant, WLH feared the transmission risk for their child and partner, worried about possible health complications, and anticipated adverse effects from HAART [8,19,101,102,105,107]. Yet, they still wanted to become pregnant and to give birth as naturally as possible. Although some WLH understood the transmission risk was low, they remained fearful and worried [8, 19, 101-103, 105, 107].
"My other fear is that my baby will come out positive. " [103] In contrast, other women considered HIV to be a death sentence. They considered the psychological impact of their health and their longevity for their children when making decisions about pregnancy [8,19,61,99,102,103].
"Am I going to get sick? Am I going to die, and the baby is going to live? I think about all of this. " [103] WLH also confronted overwhelming guilt about their HIV negative partner, past mistakes such as drug abuse, or previous decisions to give up their children for adoption [8,19,61,102,108]. Yet again, WLH expressed their desire to change the past by becoming good mothers.
"My last daughter was also born tox-positive for cocaine... and I want to change that... I want to make sure it doesn't happen again. " [102] Stigma Generally, WLH did not feel supported by family members as they did not want to hear about their pregnancy. As family members assumed WLH cannot have babies, the women experienced stigmatizing behaviors and comments [8,19,106,109,112].
"My mom told me to erase it out of my head... And it was always the same thing: I was selfish. " [109].
This stigma was also present in interactions with partners and clinicians [8,19,61,99,102,105,106,108,109].  Personal priorities and meanings are central to the negotiation of risk in sexual relationships, in which biomedical understandings of are balanced against a broader set of social expectations and desires. The need to re-negotiate a loving relationship and reproductive desires along with a desire for physical pleasure, a dislike of condoms within stable relationships and a desire to conceive without medical intervention were all given as justifications for unprotected sex in order to conceive within the context of sero-different relationship. Religious faith helps WLH embrace the uncertainties of reproduction in the context of HIV  Motherhood is viewed as a joy and as a means of meeting unmet needs but there is a concern about children's well-being. HIV infection has a minor role in HIV-positive women's lives WLH women living with HIV   [106] Feeling undermined WLH want to be loved and to have an intimate partner [61]. But occasionally their decisions were coerced by men, who forced WLH to have unprotected sex or to become pregnant [61,106]. When men knew they were HIV positive or when they became pregnant, the relationship was disrupted. In these cases, some woman felt abandoned or, on the contrary, others had subsequent unwanted pregnancies [61].
"I was always the one pushing him to use condoms, and he didn't want to. Eventually when we were living together, I just stopped. It's not always going to be my responsibility to push that." [112] Finally, WLH sometimes experienced homelessness, poverty, domestic violence, drug abuse, and other marginalizing situations. Instability in their lives made reproductive decisions difficult to manage, including whether or not to continue with unplanned pregnancies [102,109]. Some women believed having a child without the resources to create a stable family environment was irresponsible [102].
"It's not an irresponsible thing to have a child. It's an irresponsible thing to have a child without a father, without a decent income, without a place to live and without the ability to take care of this child…while dealing with your own stuff. " [102] Coping, resiliency, and support Sexuality and reproduction overlap with love, intimacy, and commitment but all are disturbed by HIV. As the WLH did not want to harm others by transmitting their HIV, they searched for approaches for safe sex or chose celibacy [61]. WLH reported barriers to using contraceptives such as cost and rejection by their partner [104]. The women needed strategies to negotiate safe sex [61,104]. This process was described as passive negotiation in studies [61,111].
"I just told them it was because you don't know where I come from, I don't know where you come from, so it is good to be careful and at the same time I don't want to get pregnant. " [111] WLH considered pregnancy planning to protect their health, as well as their partner, prior to trying to conceive [106]. Nonetheless, some women believed reproductive decisions were passive plans, even accidental situations; and they needed to assume responsibility for the consequences [102,106]. Some WLH reported lacking confidence in HAART to reduce the risk of mother-to-child transmission [107]. They believed that if the infant is born infected this is destiny [102].
"It's not really a planning thing, they just talk about it if they want to have a baby, and if it happens then it happens. " [106] Other WLH preferred to conceive without medical intervention so they engaged in unprotected sex. For these women, love and commitment with their partners was more important than the risk because childbirth should not be medicalized [105,106].
"When you find a guy and you feel comfortable with them and they accept what is going on with you, you cannot use condoms, even though you know you can get re-infected…when you are blinded by that person you take risks, I take risks, and say ain't nothing going to happen to me, ain't nothing happened to me so far so what the hell. " [106] Sharing their status with others was a coping strategy identified by WLH to accept their diagnosis. Creating empowering environments such as support groups for people to understand their situation appeared to be helpful [109].
"Surrounding myself around people that's HIV… It helps me a lot, it chills me down. " [109] However, intimate partners were the most important person for reproductive decision-making as they offered the women the self-confidence they needed to make a decision [101,105,106]. In some cases, WLH reported their relationships were stronger following HIV diagnosis due to the increased partner support [101].  [106] Despite the challenges when seeking advice about pregnancy from clinicians and family, the women wanted to make a good decision. They were not discouraged from wanting children by negative input from family members or their clinicians [106,110].
"I really don't care for…what family has to say, because …as a grown individual you have to be grown enough… to make your own decisions." [106] "Being a mother makes me grow on a personal level, but the doctor doesn't think of motherhood as medicine for the soul, a morale booster that affects me psychologically. " [110] However, WLH shared their decision with God as they believed their situation was the plan God had for them [8,19,61,99,102,108,110]. God plays an essential role in reproductive decision-making as 'He' will protect their children, so the final decision is shared with 'Him. ' [99] WLH felt relief because they could depend on spiritual forces, including the greater protection from God's power. When WLH were aware of medical advancements related to pregnancy, the possibility of becoming a mother was real [105]. Mothering gave them a reason to continue their fight against HIV as they wanted to live, and they could be stronger [8,19,61,99]. Moreover, some WLH felt they received a second chance, as they had an opportunity to correct their past parenting mistakes and to capture their missed mothering opportunities [19,108].
"However, over the years, with improvements in treatment and people with HIV living longer, it started to feel possible. The doctors told us that the risk of the baby having HIV has gone down to 1%" [105].

Discussion
Once a woman is diagnosed with HIV, life changes and identity alters. Many WLH cancel motherhood plans due to knowledge deficits, misinformation, stigma, and judgment. Being a mother is defined by their feminine identity as well as social expectations defined by the cultural context. As such, WLH seek to salvage their role as "good mothers" to stabilize their identity and to maintain their social value threatened by HIV [6]. In general, people living with HIV experience a wide range of negative emotions such as stress [113], fear [114], guilt [107], hopelessness [115], and internal stigma [116]. In the case of WLH engaged in reproductive decision-making following broken mothering opportunities, their guilt and pain is elevated.
In consonance with available evidence, this study found a lack of knowledge about the relationship between living with HIV, sexual health, and reproductive decisionmaking [21,117]. The women believed they should not become mothers, and their reproductive desires were broken by the force of this belief [117]. As Fransen and Guarinieri [24] concluded, a woman´s desire to have children is not influenced by the HIV diagnosis, but their ability to act upon this desire is blocked by the stigma resulting from the negative attitudes of people in their lives. Moreover, their sexuality is modified, and the feeling of normality is lost. In this regard, WLH experience sexual problems including decreased function and diminished desire, activity, and satisfaction compared to uninfected women [118].
The WLH wanted the support of their clinicians as they tried to understand the possibility of safely having a child [99]. Their role is essential in correcting the perception of risk in helping WLH make an informed decision about safe conception and pregnancy [24,117]. However, some studies suggested there is a persistent stigma related to pregnancy in HIV-affected couples. In this case, clinicians are more likely to ask their patients about contraception practices rather than reproductive intentions [20]. But, WLH want to be viewed as a whole person, not only as a diseased entity [18]. For these reasons, WLH perceive clinician assumptions about their sexual practices and reproductive goals are barriers to reproductive discussions. Lassi et al. [119] recommended clinicians engage in preconception counseling for women of reproductive age when they test HIV-positive as well as screening with their partners prior to pregnancy. Comprehensive reproductive health counseling for WLH is necessary, but clinicians need to be taught how to be authentically present and to be engaged in shared decision-making with HIV-affected couples [20].
From this qualitative synthesis, stigma was evidenced in the interactions WLH reported with friends, families, partners, and clinicians [20,26]. Stigma expands into marginalization, stress, uncertainty, and isolation [8].
The WLH experience insecurity about their prognoses, potential treatments, changing social relationships, and new personal identity [120]. Significant stigma for WLH results from barriers to accessing preventive services and health care [121]. WLH have similar concerns about clinician support and uncertainty about health care as people living with acute and chronic conditions.
Reproductive decision-making for each WLH is unique, as they use their repertoire of coping mechanisms to stay alive. When entering a support group for example, they can become part of a larger reality with peer support that provides collective strength [21]. Also, partner support is indispensable as they are identified as the most important person in reproductive decisionmaking [10]. Although clinicians are often not actively involved in reproductive decision-making, clinical advancements offer another opportunity for the women to correct past parenting mistakes as hope to become a good mother. Hope is capable of changing their lives and motivating the women to go forward [122] in fighting the HIV.
Generally, WLH wanted to make their own reproductive decisions despite many barriers while recognizing they needed more support. The women frequently noted spiritual forces protected them, as well as planned their lives. As such, these women felt a strong duty to care for their babies in a way that facilitated self-care. The risk of transmitting their infection to their fetus, or their partner, is their most pressing concern [6,18]. They also fear death because they do not want to abandon their children [123]. Spirituality becomes an effective coping mechanism for WLH to provide meaning, guidance, support, protection, and inner strength [124][125][126][127].

Study limitations
There are several limitations to consider. First, the synthesis relied on the analyzed data from each article that might not reflect the meaning from the raw data. Second, to synthesize studies from countries with comparable social wellbeing and economic conditions, the search was limited to OECD member countries. As such, the review may not be generalizable to developing countries. In addition, almost half the included studies were conducted in urban areas of the United States which may further limit the generalizability of the findings within the target countries. Despite these limitations, the search included multiple languages due to the multinational team, extensive database searches, and comparable environments. Third, the studies spanned almost three decades, defined by the period of HAART. Despite the wide span, there was data consistency across the decades. Fourth, the systematic review was completed from 1995 to 2018 with an update in 2019 introducing an increased possibility for search bias. However, the broad search strategy minimized the impact of this concern. Finally, the search might have excluded studies not published in non-indexed journals or in different contexts, such as thesis or dissertations. However, the search strategy and the database selection were based on published recommended practices.

Conclusion
For WLH, reproductive decision-making is a complex process based upon incomplete information and inaccurate perspectives. In developed countries, WLH engage in reproductive decision-making more frequently due to advances in pharmaceuticals and better evidence-based practices while receiving limited assistance from family, friends, partners, and clinicians. Decisions regarding reproduction are individual but women are not able to make an informed decision without guidance and medical consultation. Clinicians need to be authentically present for discussions and open to the new possibilities for WLH in the context of the modern person-centered health system. An integrated approach with comprehensive multidisciplinary counseling is necessary to address reproductive decision-making and sexual health as a right. Clinicians need to initiate discussions for WLH in the same way as other women.
In clinical practice, WLH should be engaged with a human caring approach to identify personal preferences, consider individual situations, and provide person-centered care. Clinicians should learn to collaborate with WLH in reproductive decision-making through regular family planning conversations and routine sexual health assessments. For more effective relationships with WLH, clinicians need to be authentically present, including demonstrating compassion and understanding to minimize the stigma associated with sexual health. Finally, evidence-based practice guidelines for sexual health and family planning need to be developed for WLH to consistently deliver culturally competent, integrated, and holistic person-centered care.