Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: A prospective study

Table 2 Metabolic variables before and after 4 months with SCI

Variable	Basal	4 months	p	Reference values
Glucose [mg/dl]	91.3 (80.7-116.6)	85.4 (66.0-100.2)	0.034	65-114
Urea [mg/dl]	21.8 (14.4-29.0)	20.7 (12.8-28.8)	0.405	15-39
Creatinine [mg/dl]	0.59 (0.4-0.7)	0.60 (0.5-0.8)	0.179	0.5-1.2
Uric acid [mg/dl]	4.5 (2.7-6.1)	4.2 (3.0-6.3)	0.418	2.6-7.2
TG [mg/dl]	136.9 (64.5-244.7)	104.1 (34.7-220.3)	0.002	54-214
TC [mg/dl]	163.7 (118.2-214.1)	144.6 (93.0-206.2)	0.001	140-220
HDL-C [mg/dl]	38.2 (20.6-60.8)	38.7 (25.0-58.4)	0.751	21-75
LDL-C [mg/dl]	98.0 (66.2-145.8)	84.7 (48.4-124.2)	0.012	56-155
VLDL-C [mg/dl]	27.3 (12.9-48.9)	20.8 (6.9-44.1)	0.025
AI	4.54 (2.7-6.4)	3.83 (2.2-5.3)	0.002	<4
TB [mg/dl]	0.63 (0.2-1.2)	0.56 (0.3-1.0)	0.121	0.2-1.0
DB [mg/dl]	0.08 (0.0-0.1)	0.11 (0.1-0.2)	0.050	0.0-0.2
IB [mg/dl]	0.55 (0.2-1.1)	0.45 (0.2-0.8)	0.025
SGOT [U/l]	25.2 (15.1-48.0)	22.3 (13.2-32.0)	0.167	15-37
SGPT [U/l]	24.9 (10.0-59.3)	21.5 (8.7-39.5)	0.081	8-35
AP [U/l]	80.2 (58.2-144.9)	75.8 (48.7-121.7)	0.093	37-110
LDH [U/l]	144 (110.8-190.0)	154.5 (115.6-195.9)	0.005	106-274
GGT [U/l]	21.7 (5.7-68.6)	26.9 (7.0-76.4)	0.009	5-24
TP [g/dl]	7.0 (6.3-7.6)	7.2 (6.8-7.8)	0.121	6.7-8.2
Alb [g/dl]	4.1 (3.7-4.6)	4.3 (3.9-4.8)	0.132	3.8-5.1
Glb [g/dl]	2.84 (2.3-3.1)	2.83 (2.4-3.3)	0.747

Results are expressed as medians (percentiles: 2.5-97.5). Reference values (RV) for metabolic variables are showed in the fifth column. Significant p values are shown in bold. Glucose (p = 0.012), triglycerides (TG; p < 0.001), total cholesterol (TC; p < 0.001), serum glutamic oxaloacetic transaminase (SGOT; p = 0.002), serum glutamic pyruvic transaminase (SGPT; p < 0.001), alkaline phosphatase (AP; p = 0.001), total bilirubin (TB; p = 0.027), indirect bilirubin (IB; p = 0.008), albumin (Alb; p = 0.027), globulins (Glb; p = 0.020), very-low-density lipoprotein cholesterol (VLDL-C; p < 0.001), gammaglutamyl transferase (GGT; p < 0.001), and high sensitivity C-reactive protein (hsCRP; p = 0.002), had an abnormal distribution. SCI: subdermal contraceptive implant; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; AI: atherogenic index; DB: direct bilirubin; LDH: lactate dehydrogenase; and TP: total proteins. Kolmogorov Smirnov test was used to establishing the distribution of variables. Mann-Whitney U test and Wilcoxon test were used in order to analyze non-parametric values. Student t test and paired t tests were used for parametric variables.

ISSN: 1742-4755