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Table 2 Assessment of available evidence: number of included systematic reviews and primary studies and GRADE rating of quality of evidence for predefined comparisons and outcomes of interest

From: Assisted reproductive technologies (ARTs): Evaluation of evidence to support public policy development

Outcome of interest Spontaneous conception (17 reviews; no additional primary studies) Less invasive ARTs – OI/IUI (2 reviews; no additional primary studies) Number of embryos (6 reviews; no additional primary studies) State of embryos – fresh/frozen (5 reviews; no additional primary studies) Stage of embryos – blastocyst/cleavage (5 reviews; 2 additional primary studies) Source of embryos – autologous/donor 1 review; 1 additional primary study)
Effectiveness:       
• Cycle success (cancellation, implantation) * * 2 reviews * 2 reviews *
   Low to Moderate   Moderate  
• Pregnancy, miscarriage, and live birth 1 review 1 review 6 reviews 2 reviews 2 reviews 1 primary study
Moderate Moderate Low to Moderate Low to Moderate Moderate Low
• Multiple pregnancy/birth * 1 review 3 reviews * 2 reviews *
  Moderate Low to Moderate   Moderate  
Safety:       
• Pregnancy and delivery complications 5 reviews 1 review 3 reviews 5 reviews 2 primary studies 1 review
Very Low to Low Very Low to Moderate Low to Moderate Very Low to Moderate Low Low to Very Low
• neonatal/infant complications 15 reviews * 2 reviews 3 reviews 2 primary studies 1 review
Very Low to Low   Low to Moderate Low to Moderate Low Low to Very Low
  1. *Blanks indicate no reviews or primary studies were found.