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Table 2 The clinical characteristics and metabolic profiles in different PCOS phenotypes and control women

From: A case–control observational study of insulin resistance and metabolic syndrome among the four phenotypes of polycystic ovary syndrome based on Rotterdam criteria

Parameters A n = 139 B n = 10 C n = 36 D n = 78 E-Control n = 263 P-value
Age (years) 26.96 ± 4.67b,e 32.70 ± 2.71a,c,d,e 26.64 ± 4.86e 25.76 ± 5.19e 29.02 ± 6.03a,b,c,d <0.001
Waist (cm) 100.85 ± 12.42d,e 103.50 ± 8.71e 96.86 ± 14.08 97.10 ± 14.5e 93.25 ± 12.05a,b,d <0.001
Waist/hip ratio 0.92 ± 0.06e 0.95 ± .05e 0.91 ± 0.09 0.91 ± 0.08 0.89 ± 0.07 a,b 0.001
BMI (kg/m2) 31.79 ± 5.79c,e 32.83 ± 4.83e 29.41 ± 5.67a 30.36 ± 5.88e 28.66 ± 5.04a,b,d <0.001
Systolic blood pressure (mmHg) 126.37 ± 12.46d,e 129.50 ± 13.01 122.78 ± 10.92 123.14 ± 10.99a 123.25 ± 11.28a 0.043
Diastolic blood pressure (mmHg) 82.81 ± 8.82 84.50 ± 4.97 80.42 ± 8.31 81.67 ± 6.67 81.29 ± 7.42 0.214
Cholesterol (mg/dL) 176.70 ± 31.66c,e 177.40 ± 31.39 162.44 ± 27.11a 168.35 ± 42.30 165.29 ± 32.59e 0.015
Triglycerides (mg/dL) 130.37 ± 90.88e 144.50 ± 45.32e 105.61 ± 59.51 124.33 ± 93.93e 96.73 ± 57.15 a,b,d <0.001
HDL(mg/dL) 43.74 ± 9.70 42.78 ± 8.12 43.99 ± 9.96 43.59 ± 9.86 45.22 ± 8.84 0.450
LDL (mg/dL) 85.08 ± 24.79c,d,e 83.70 ± 20.90 74.05 ± 17.21a 78.44 ± 24.19a 77.31 ± 21.87a 0.010
TG/HDL (CV risk)* 3.31 ± 3.45e 3.44 ± 1.15 2.69 ± 1.95 3.12 ± 2.807e 2.28 ± 1.6a,d 0.001
Fasting glucose (FG) 91.29 ± 19.74 93.70 ± 16.02 87.58 ± 10.1 91.58 ± 13.04 90.01 ± 12.3 0.555
2-h glucose 129.45 ± 49.9e 128.90 ± 30.76 124.36 ± 53.95 121.73 ± 38.49e 116.06 ± 28.52a,d 0.022
Fasting insulin (FI) 16.86 ± 11.41e 18.52 ± 11.18e 14.51 ± 7.65e 14.76 ± 8.22 e 10.74 ± 5.61a,b,c,d <0.001
2-h insulin 103.63 ± 74.65d,e 101.91 ± 81.45e 93.60 ± 69.4e 75.29 ± 53.01a,e 59.15 ± 39.2a,b,c,d <0.001
Fasting glucose/fasting insulin 7.30 ± 4.40e 7.21 ± 4.78e 8.14 ± 4.87e 8.46 ± 6.64e 10.64 ± 5.89a,b,c,d <0.001
Ratio of 2-h glucose to 2-h insulin 1.86 ± 1.40e 1.56 ± 0.84e 2.04 ± 1.66e 2.15 ± 1.17e 2.58 ± 1.40a,b,c,d 0.001
Matsuda index 4.81 ± 3.449e 5.01 ± 4.19 6.02 ± 5.33 5.58 ± 3.28e 7.19 ± 4.13a,d 0.001
HOMA-IR 3.873 ± 2.99e 4.48 ± 3.27e 3.19 ± 1.86e 3.46 ± 2.29e 2.41 ± 1.42a,b,c,d <0.001
HOMA-B 237.14 ± 163.32e 245.35 ± 139.7 227.93 ± 162.2e 210.21 ± 138.2e 161.93 ± 105.27a,c,d 0.001
QUICKI 0.32 ± 0.02e 0.32 ± 0.03e 0.33 ± 0.03e 0.32 ± 0.03e 0.34 ± 0.02a,b,c,d <0.001
  1. Values are presented as mean ± standard deviation. P-values were calculated using one-way ANOVA followed by multiple comparisons (post hoc test (least significance difference (LSD)).
  2. *(TG/HDL) Triglyceride/ high-density lipoprotein (fasting), CV: cardiovascular risk.
  3. aP < 0.05 versus phenotype A PCOS, bP < 0.05 versus phenotype B PCOS, cP < 0.05 versus phenotype C PCOS, dP < 0.05 versus phenotype D PCOS, eP < 0.05 versus control.
  4. (Note: (i) Phenotype A (O + H + P), (ii) Phenotype B (O + H), (iii) Phenotype C (H + P) and (iv) Phenotype D (O + P). A: Oligo-anovulation (O), + Hyperandrogenism (H), + Polycystic ovaries morphology (P).