Dysfunctional system | Clinical criteria | Laboratory markers | Management based proxies |
---|---|---|---|
Cardiovascular | • Shock (a) | • pH<7.1 | • Use of continuous vasoactive drugs (i) |
 | • Cardiac arrest (b) | • Lactate>5 mEq/mL | • Cardio-pulmonary resuscitation (CPR) |
Respiratory | • Acute cyanosis | • Oxygen saturation < 90% for ≥ 60 minutes | • Intubation and ventilation not related to anaesthesia |
 | • Gasping (c) | • PaO2/FiO2<200 mmHg |  |
 | • Respiratory rate >40 or <6 bpm |  |  |
Renal | • Oliguria non responsive to fluids or diuretics (d) | • Creatinine ≥ 300 μmol/l or ≥ 3.5 mg/dL | • Dialysis for acute renal failure |
Haematologic/ Coagulation | • Failure to form clots(e) | • Acute severe thrombocytopa-enia (<50,000 platelets/ml) | • Transfusion of ≥ 5 units of blood/red cells |
Hepatic | • Jaundice in the presence of preeclampsia (h) | • Bilirubin >100 μmol/l or >6.0 mg/dL |  |
Neurologic | • Any loss of consciousness lasting >12 h (f) |  |  |
 | • Stroke (g) |  |  |
 | • Uncontrollable fit/status epilepticus |  |  |
 | • Total paralysis |  |  |
Alternative severity proxy |  |  | • Hysterectomy following infection or haemorrhage |