Extremely preterm birth (less than 28 weeks of gestation) | |||||||
---|---|---|---|---|---|---|---|
Study ID | Country | Study design | Sample size | Description of women/patients with preterm labour | Intervention (description) | Comparison | Outcome |
Berghella 2009 [27] | USA | Retrospective cohort (January 1998 - December 2005) | 222 (n = 68 vs. n = 154) | Women between 14 and 25 week of gestation with suspected cervical dilation ≥1 cm. | Indomethancin plus some with cerclage | No treatment plus some with cerclage | Prolongation of pregnancy >28, 32, or 35 weeks |
(50 mg orally, followed by 25 mg orally every 6 h for a maximum of 48 h) | Perinatal death | ||||||
Birth weight >1500 grams | |||||||
Cape 2010 [26] | USA | Retrospective cohort (2003–2008) | a138 neonates (n = 69 vs. n = 69) | All women less than 29 weeks of gestation with threaten with premature rupture of membranes. | Indomethancin | No treatment | Neonatal outcomes only including intraventricular hemorrhage, necrotizing enterocolitis, patent ductus arteriosus, and spontaneous intestinal perforations |
Manuck 2012 [25] | USA | Retrospective cohort (January 2000 – June 2011) | 148 (n = 84 vs. n = 64) | Women with a singleton non-anomalous fetus with spontaneous preterm labour and intact membranes, between 20–23.9 week of gestation, and with cervical dilation ≥ 1 cm and effaced > 50 %. | Tocolytic medication | No treatment | Prolongation of pregnancy >7 days |
(Database record of tocolytic treatment used i.e. magnesium sulfate, indomethacin or nifedipine, either used singly or in combination) | Perinatal death | ||||||
Visintine 2008 [24] | USA | Retrospective cohort (1995–2006) | 101 (n = 51 vs. n = 50) | Asymptomatic women followed from 14 weeks through 23 weeks 6 days gestation with a short cervical length, defined as <25 mm, placed with an ultrasound-indicated cerclage. | Indomethacin plus cerclage | Cerclage only | Prolongation of pregnancy >24, 32, or 35 weeks |
(50 mg initially orally or rectally, followed by 25 mg orally every 6 h for about 48 h.) | |||||||
Multiple gestations | |||||||
No report found for tocolytic treatment for imminent risk of preterm labor | |||||||
Growth-restricted fetuses | |||||||
No report found for tocolytic treatment for imminent risk of preterm labor |