Skip to main content

Table 2 Drug and vaccines trials proposed, initiated, or completed during the 2013–2016 Ebola virus disease epidemic in Guinea, Liberia, and Sierra Leone

From: Protected to death: systematic exclusion of pregnant women from Ebola virus disease trials

Clinical trial registry ID Study type (Phase)a Intervention Scientific title [References to publications] Country Status WHO-ERC Review (WHO-supported) Pregnant women excluded (test)a,b
ISRCTN17414946 Treatment (NS) IFN ß-1a A pilot study to evaluate the safety and efficacy of interferon beta-1a (IFN ß-1a) in the treatment of patients presenting with Ebola virus illness Guinea <10 patients enrolled, results pending [73] No (No) Yes (NS)
PACTR201411000939962 Treatment (NS) Brincidofovir Open-label, non-randomised single arm trial to investigate the efficacy of brincidofovir compared to historic controls for Ebola virus disease in an outbreak setting in West Africa (RAPIDE-BCV) [32] Liberia Completed Yes (No) Yes (Yes)
NCT02329054 Treatment (2) Favipiravir Efficacy of favipiravir in reducing mortality in individuals with Ebola Virus Disease in Guinea (JIKI) [38] [74] Guinea Completed Yes (No) Yes (Yes)
NCT02662855 Treatment (2) Favipiravir Efficacy of favipiravir against severe Ebola virus disease Sierra Leone Completed No (No) Yes (NS)
ChiCTR-OCN-15007272 Treatment (NS) Favipiravir Clinical and virological characteristics of Ebola Virus Disease patients treated with favipiravir (T-705) - Sierra Leone, 2014 [75] Sierra Leone Completed No (No) NS (NS)
PACTR201501000997429 Treatment (NS) TKM-130803 Open-label, single arm trial to investigate the efficacy of TKM-130803 with a concurrent observational study of Ebola virus Disease in an outbreak setting in West Africa (RAPIDE TKM) [40] [76] Sierra Leone Completed No (No) Yes (Yes)
NCT02363322 Treatment (1/2) ZMapp A multicenter randomized safety and efficacy study of putative investigational therapeutics in the treatment of patients with known Ebola infection [77] Guinea, Liberia, Sierra Leone Ongoing, not recruiting No (No) Yes (Yes)
NCT02333578 Treatment (NS) Convalescent plasma A phase I/II pilot clinical trial to evaluate the efficacy and safety of Ebola virus disease (EVD) convalescent plasma (ECP) for treatment of EVD Liberia Recruiting No (No) Yes (Yes)
NCT02342171 Treatment (2/3) Convalescent plasma Emergency evaluation of convalescent plasma for ebola viral Disease (EVD) in Guinea [39] [30] [78] Guinea (MSF ETC Conakry) Completed Yes (Yes) No
ISRCTN13990511 Treatment (2/3) Convalescent Plasma Convalescent plasma for early Ebola virus disease in Sierra Leone: an open-label, non-randomized, controlled clinical trial Sierra Leone Completed No (No) No
NCT02509494, PACTR201506001147964 Vaccine (3) Ad26.ZEBOV MVA-BN-Filo A staged Phase 3 study, including a double-blinded controlled stage to evaluate the safety and immunogenicity of Ad26.ZEBOV and MVA-BN-Filo as candidate prophylactic vaccines for Ebola Sierra Leone Recruiting No (No) Yes (Yes)
NCT02575456 Vaccine (2) Ad5-EBOV A single-center, randomized, blind, Phase II clinical trial to evaluate the safety and immunogenicity of the Adenovirus Type 5 Vector Based Ebola Virus Disease Vaccine (Ad5-EBOV) in healthy adults in Sierra Leone Sierra Leone Completed No (No) Yes (Yes)
NCT02876328 Vaccine (2) Ad26.ZEBOV, rVSVΔG/ ZEBOV-GP MVA-BN-Filo Partnership for research on Ebola vaccinations (PREVAC) Guinea, Liberia Recruiting No (No) Yes (Yes)
PACTR201503001057193 Vaccine (3) rVSVΔG/ ZEBOV-GP A randomized trial to evaluate Ebola vaccine efficacy and safety in Guinea, West Africa. Part A: A randomized trial of ring vaccination to evaluate Ebola vaccine efficacy and safety in Guinea, West Africa. Part B: Safety and immunogenicity of rVSVΔG/ ZEBOV-GP among frontline workers [43] [72] Guinea, Sierra Leone Completed Yes (Yes) Yes (self-reported, non-obligatory test offered)
NCT02378753, PACTR201502001037220 Vaccine (2/3) rVSVΔG/Z EBOV-GP rVSVΔG-ZEBOV Ebola prevention vaccine evaluation in Sierra Leone (STRIVE) Sierra Leone Completed No (No) Yes (Yes)
NCT02344407 Vaccine (2) rVSVΔG/ ZEBOV-GP, ChAd3-EBOZ Partnership for research on Ebola vaccines in Liberia (PREVAIL) Liberia Active, not recruiting No (No) Yes (Yes)
  1. Source: WHO International Trial Registry Platform (http://apps.who.int/trialsearch/Default.aspx) and referenced publications
  2. a NS not specified, btest-negative pregnancy test required