The Pregnancy and Influenza Multinational Epidemiologic (PRIME) study: a prospective cohort study of the impact of influenza during pregnancy among women in middle-income countries

Table 1 Site characteristics, the Pregnancy and Influenza Multinational Epidemiologic Study

	Bangkok, Thailand	Lima, Peru	Nagpur, India
Primary research institution(s)	Queen Sirikit National Institute of Child Health, Thailand Ministry of Public Health Thailand Ministry of Public Health—US Centers for Disease Control and Prevention Collaboration	U.S. Naval Medical Research Unit No. 6 (NAMRU-6)	Lata Medical Research Foundation
Study laboratory^a	Armed Forces Research Institute of Medical Sciences	NAMRU-6 Virology and Emerging Infections Laboratory	Dhruv Pathology and Diagnostic Laboratory (year 1)
Source population	Pregnant women attending outpatient prenatal care visits at study hospitals	Pregnant women attending outpatient prenatal care visits at study hospitals	Pregnant women from urban Nagpur attending outpatient prenatal care visits at study hospitals
Study hospitals
Number	2	4	1
Types	Tertiary/referral	Tertiary/referral	Secondary/referral
Institutions (deliveries/year)	Nopparat Hospital (6000) Rajavithi Hospital (6000-7000)	Peruvian Maternal and Perinatal Institute (22000) Arzobispo Loayza National Hospital (4000) Dos de Mayo National Hospital (4000) San Bartolome Hospital (7000)	Daga Memorial Government Women’s Hospital (14000-15000)
Start date of local influenza season^b (epidemiologic week)	28	18	26

^aStudy laboratories process and test respiratory specimens for influenza viruses by reverse transcription polymerase chain reaction (RT-PCR) using US Centers for Disease Control and Prevention protocols. In Thailand, the study laboratory also tests for respiratory syncytial viruses and human metapneumoviruses by RT-PCR
^bFor the purposes of recruitment and enrollment, the ‘influenza season’ is defined as the 16 week time period in which influenza epidemics are most likely to occur as predicted by local influenza virus surveillance data from previous years

ISSN: 1742-4755