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Table. 3 Genotype distribution of eNOS 894 G/T, Intron 4b/4a, -786 T/C, -2051 G/A and -1861G/A haplotypes in controls and preeclamptic groups

From: Association of endothelial nitric oxide synthase gene variants with preeclampsia

eNOS Variants

Genotype and Alleles

Controls

(total n = 300)

n (%)

PE with mild features

(total n = 188)

n (%)

PE with severe features

(total n = 112)

n (%)

Total preeclamptic women

(total n = 300)

n (%)

c.894G > T or p.(Glu298Asp)

GG

225 (75)

125 (66.4)

73 (65.2)

198 (66)

rs1799983

TC

43 (14.5)

23 (12.3)

14 (12.5)

36 (12)

 

TT

32 (10.5)

40 (21.3)

25 (22.3)

66 (22)*

   

(χ2 = 7.56, p = 0.023)

(χ2 = 6.79, P = 0.033)

(χ2 = 9.75, P = 0.008)

 

Allele Frequency

    
 

G (Glu)

493 (82.25)

272 (72.3)

160 (71.4)

432 (72)

 

T (Asp)

107 (17.75)

104 (27.7)

64 (28.6)

168 (28)

   

(χ2 = 22.78 p ≤ 0.001)

(χ2 = 7.91, p = 0.004)

(χ2 = 11.91, p ≤ 0.001)

   

OR = 2.27 (1.61–3.2)

OR = 1.862 (1.20–2.88)

OR = 1.80 (1.28–2.52)

Intron 4a/4b

Bb

272 (90.5)

159 (84.6)

99 (88)

258 (86)

rs1722009

Ba

28 (9.5)

29 (15.4)

13 (12)

42 (14)

 

Aa

0

0

0

0

   

(χ2 = 2.42, p = 0.08)

(χ2 = 0.37, p = 0.34)

(χ2 = 1.95, p = 0.1)

 

Allele Frequency

    
 

B

572 (95.25)

347 (92.3)

210 (94)

558 (93)

 

A

28 (4.75)

29 (7.7)

14 (6)

42 (7)

   

(χ2 = 2.51, p = 0.08)

(χ2 = 0.43, p = 0.32)

(χ2 = 2.07, p = 0.09)

   

OR = 1.69 (0.87–3.26)

OR = 1.31 (0.58–2.97)

OR = 1.54 (0.85–2.82)

g.-786 T > C

TT

204 (68)

107 (56.9)

63 (56)

169 (56.5)

rs2070744

TC

79 (26.5)

61 (32.4)

45 (40)**

104 (34.5)**

 

CC

17 (5.5)

20 (10.7)*

4 (4)

27 (9)*

   

(χ2 = 7.19, P = 0.02)

(χ2 = 7.24, P = 0.02)

(χ2 = 7.84, P = 0.02)

 

Allele Frequency

    
 

T

487 (81.25)

272 (72.3)

170 (76)

442 (73.75)

 

C

113 (18.75)

104 (27.7)

54 (24)

158 (26.25)

   

(χ2 = 6.98, p = 0.006)

(χ2 = 1.86, p = 0.1)

(χ2 = 6.45, p = 0.007)

   

OR = 1.65 (1.13–2.40)

OR = 1.36 (0.87–2.14)

OR = 1.54 (1.10–2.15)

g.-2051G > A

GG

230 (76.5)

117 (62.3)

79 (70.5)

196 (65.5)

rs553827594

GA

51 (17)

36 (19.1)

10 (9)

47 (15.5)

 

AA

19 (6.5)

35 (18.6)**

23 (20.5)**

57 (19)***

   

(χ2 = 12.19, P = 0.002)

(χ2 = 12.16, P = 0.002)

(χ2 = 7.45, P = 0.02)

 

Allele Frequency

    
 

G

511 (85)

270 (72)

168 (75)

439 (73.25)

 

A

89 (15)

106 (28)

56 (25)

161 (26.75)

   

(χ2 = 16.25, p < 0.001)

(χ2 = 7.01, p = 0.008)

(χ2 = 6.45, p = 0.007)

   

OR = 2.10 (1.49–3.25)

OR = 1.85 (1.16–2.44)

OR = 1.85 (1.17–2.94)

g.-1861G > A

GG

212 (71)

123 (65.4)

78 (69.7)

201 (67)

rs1800779

GA

83 (27.5)

59 (31.2)

26 (23.2)

85 (28.5)

 

AA

5 (1.5)

6 (3.2)

8 (7.1)*

14 (4.5)

   

(χ2 = 1.72, P = 0.42)

(χ2 = 5.27, P = 0.07)

(χ2 = 3.26, P = 0.19)

 

Allele Frequency

    
 

G

507 (84.75)

305 (81.2)

182 (81.25)

487 (81.25)

 

A

93 (15.25)

71 (18.8)

42 (18.75)

113 (18.75)

   

(χ2 = 1.39, p = 0.23)

(χ2 = 0.93, p = 0.33)

(χ2 = 1.73, p = 0.18)

   

OR = 1.28 (0.84–1.95)

OR = 1.27 (0.77–2.08)

OR = 1.28 (0.88–1.85)

  1. *p ≤ 0.05 and **p ≤ 0.01 is significant for Pearson chi-square test to identify which genotype presents significant different frequencies
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Reproductive Health

ISSN: 1742-4755