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Table. 3 Genotype distribution of eNOS 894 G/T, Intron 4b/4a, -786 T/C, -2051 G/A and -1861G/A haplotypes in controls and preeclamptic groups

From: Association of endothelial nitric oxide synthase gene variants with preeclampsia

eNOS Variants Genotype and Alleles Controls
(total n = 300)
n (%)
PE with mild features
(total n = 188)
n (%)
PE with severe features
(total n = 112)
n (%)
Total preeclamptic women
(total n = 300)
n (%)
c.894G > T or p.(Glu298Asp) GG 225 (75) 125 (66.4) 73 (65.2) 198 (66)
rs1799983 TC 43 (14.5) 23 (12.3) 14 (12.5) 36 (12)
  TT 32 (10.5) 40 (21.3) 25 (22.3) 66 (22)*
   2 = 7.56, p = 0.023) 2 = 6.79, P = 0.033) 2 = 9.75, P = 0.008)
  Allele Frequency     
  G (Glu) 493 (82.25) 272 (72.3) 160 (71.4) 432 (72)
  T (Asp) 107 (17.75) 104 (27.7) 64 (28.6) 168 (28)
   2 = 22.78 p ≤ 0.001) 2 = 7.91, p = 0.004) 2 = 11.91, p ≤ 0.001)
    OR = 2.27 (1.61–3.2) OR = 1.862 (1.20–2.88) OR = 1.80 (1.28–2.52)
Intron 4a/4b Bb 272 (90.5) 159 (84.6) 99 (88) 258 (86)
rs1722009 Ba 28 (9.5) 29 (15.4) 13 (12) 42 (14)
  Aa 0 0 0 0
   2 = 2.42, p = 0.08) 2 = 0.37, p = 0.34) 2 = 1.95, p = 0.1)
  Allele Frequency     
  B 572 (95.25) 347 (92.3) 210 (94) 558 (93)
  A 28 (4.75) 29 (7.7) 14 (6) 42 (7)
   2 = 2.51, p = 0.08) 2 = 0.43, p = 0.32) 2 = 2.07, p = 0.09)
    OR = 1.69 (0.87–3.26) OR = 1.31 (0.58–2.97) OR = 1.54 (0.85–2.82)
g.-786 T > C TT 204 (68) 107 (56.9) 63 (56) 169 (56.5)
rs2070744 TC 79 (26.5) 61 (32.4) 45 (40)** 104 (34.5)**
  CC 17 (5.5) 20 (10.7)* 4 (4) 27 (9)*
   2 = 7.19, P = 0.02) 2 = 7.24, P = 0.02) 2 = 7.84, P = 0.02)
  Allele Frequency     
  T 487 (81.25) 272 (72.3) 170 (76) 442 (73.75)
  C 113 (18.75) 104 (27.7) 54 (24) 158 (26.25)
   2 = 6.98, p = 0.006) 2 = 1.86, p = 0.1) 2 = 6.45, p = 0.007)
    OR = 1.65 (1.13–2.40) OR = 1.36 (0.87–2.14) OR = 1.54 (1.10–2.15)
g.-2051G > A GG 230 (76.5) 117 (62.3) 79 (70.5) 196 (65.5)
rs553827594 GA 51 (17) 36 (19.1) 10 (9) 47 (15.5)
  AA 19 (6.5) 35 (18.6)** 23 (20.5)** 57 (19)***
   2 = 12.19, P = 0.002) 2 = 12.16, P = 0.002) 2 = 7.45, P = 0.02)
  Allele Frequency     
  G 511 (85) 270 (72) 168 (75) 439 (73.25)
  A 89 (15) 106 (28) 56 (25) 161 (26.75)
   2 = 16.25, p < 0.001) 2 = 7.01, p = 0.008) 2 = 6.45, p = 0.007)
    OR = 2.10 (1.49–3.25) OR = 1.85 (1.16–2.44) OR = 1.85 (1.17–2.94)
g.-1861G > A GG 212 (71) 123 (65.4) 78 (69.7) 201 (67)
rs1800779 GA 83 (27.5) 59 (31.2) 26 (23.2) 85 (28.5)
  AA 5 (1.5) 6 (3.2) 8 (7.1)* 14 (4.5)
   2 = 1.72, P = 0.42) 2 = 5.27, P = 0.07) 2 = 3.26, P = 0.19)
  Allele Frequency     
  G 507 (84.75) 305 (81.2) 182 (81.25) 487 (81.25)
  A 93 (15.25) 71 (18.8) 42 (18.75) 113 (18.75)
   2 = 1.39, p = 0.23) 2 = 0.93, p = 0.33) 2 = 1.73, p = 0.18)
    OR = 1.28 (0.84–1.95) OR = 1.27 (0.77–2.08) OR = 1.28 (0.88–1.85)
  1. *p ≤ 0.05 and **p ≤ 0.01 is significant for Pearson chi-square test to identify which genotype presents significant different frequencies