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Towards elimination of maternal deaths: maternal deaths surveillance and response
© Hounton et al.; licensee BioMed Central Ltd. 2013
Received: 5 October 2012
Accepted: 24 December 2012
Published: 2 January 2013
Current methods for estimating maternal mortality lack precision, and are not suitable for monitoring progress in the short run. In addition, national maternal mortality ratios (MMRs) alone do not provide useful information on where the greatest burden of mortality is located, who is concerned, what are the causes, and more importantly what sub-national variations occur. This paper discusses a maternal death surveillance and response (MDSR) system. MDSR systems are not yet established in most countries and have potential added value for policy making and accountability and can build on existing efforts to conduct maternal death reviews, verbal autopsies and confidential enquiries. Accountability at national and sub-national levels cannot rely on global, regional and national retrospective estimates periodically generated from academia or United Nations organizations but on routine counting, investigation, sub national data analysis, long term investments in vital registration and national health information systems. Establishing effective maternal death surveillance and response will help achieve MDG 5, improve quality of maternity care and eliminate maternal mortality (MMR ≤ 30 per 100,000 by 2030).
Of all Millennium Development Goals (MDGs), improving maternal health (MDG 5) is the least likely to be achieved. Despite knowledge on determinants and causes, and effective clinical and public health strategies , the goal of reducing, the maternal mortality ratio (MMR) between 1990 and 2015 by three quarters is unlikely to be met. More than ever before, maternal and newborn health has received heightened attention from the United Nations, governments, non-governmental organizations, and civil society . The Commission on Information and Accountability of the Global Strategy for Women’s and Children’s Health recommended the implementation of an accountability framework that in countries is based on national oversight, accurate and comprehensive monitoring of results, regular multi-stakeholder review of data and responses, all key features of traditional surveillance and response systems. Significant reduction of maternal mortality in countries will require counting every case and collection of information to permit an effective response that prevents future deaths . Thus a maternal death surveillance and response (MDSR) Technical Working Group (TWG) has been established and chaired by the World Health Organization. The overall objectives of the MDSR are: 1) To provide information that effectively guides actions to eliminate preventable maternal mortality at health facilities and in the community; and 2) To count every maternal death, permitting an assessment of the true magnitude of maternal mortality and the impact of actions taken to reduce it . The upcoming technical guidance of MDSR by the World Health Organization will provide comprehensive concepts of MDSR. This paper describes why MDSR is needed and what would be entailed, builds on lessons from communicable disease surveillance, and considers the pre-requisites for widespread implementation.
Eliminating maternal mortality
The vision ‘no woman should lose her life when giving birth’ reflects the human rights perspective on maternal mortality and would require that 90% of maternal deaths (when diagnosed and treated in a timely manner) , be avoided, making maternal mortality a potential target for an elimination strategy. The term elimination in this paper refers to a significantly lowered level to the point at which maternal mortality ceases to be a major public health burden in countries (for example a goal of a MMR ≤ 30 per 100,000 by 2030  although other target dates such as 2035 or much closer 2025 are being considered).
Although pregnancy is not a disease and maternal death is non-communicable, the good and bad outcomes (births, deaths, complications for mothers and newborns and subsequent disabilities) are all relevant to public health. All issues carrying the burdens of mortality and morbidity warrant public health surveillance systems, and although most have been established for communicable diseases, similar principles could be applied to maternal events [6–8].
Paradigm shift: why MDSR and what is its added value?
Rationale for MDSR
Tracking progress on maternal mortality ratios or rates is notoriously difficult given the lack of reliable vital registration in developing countries and problems in the ascertainment of pregnancy status especially in its early stages. Current national MMR estimates are generated by United Nations agencies and academia despite the absence of civil vital registration and the difficulties in capturing maternal deaths [9–11]. These estimates use aggregated national figures, which lack precision; are not timely, referring to the past; and are often not readily available in formats like simple maps or trend diagrams. Current methods in many developing countries use large-scale periodic surveys (national censuses, Demographic and Health Surveys, Multiple Indicator Cluster Surveys, etc.), which are expensive and data are retrospective and not released in a timely manner. These estimates carry wide confidence intervals and often provide no clues for action. Such estimates are often disputed by countries, and not acted upon. Efforts to generate national estimates have usually ignored the equity dimension of maternal mortality within countries, mainly because of large sample size errors that are associated with survey methodologies for relatively rare events . MDSR would assist in computing national, country-owned maternal mortality data, as well as provide more reliable MMR at sub national levels, thereby showing where the greatest burden of mortality is located, who is concerned and what the causes are. MDSR can inform the actions needed to prevent maternal deaths both in the community and in health facilities. MDSR can improve the quality of care provided to pregnant women by identifying gaps in health services that contributed to a maternal death.
Data are needed to enable short term progress tracking, intervention evaluation, timely actions and increased accountability of civil society, policy makers, managers and donors at national and sub-national levels. These data must be locally relevant, ‘fit for purpose’, inform an immediate response system and be presented in simple table and graphic formats with stories that are powerful and which catalyze action – hence creating accountability. This, together with improvements in health information systems, requires a paradigm shift in counting and responding to maternal deaths instead of solely providing numerical estimates.
Added value of MDSR
Public health surveillance involves continuous interpretation of data, essential for the planning, implementation and evaluation of public health practice [13, 14]. Surveillance in principle can be either passive or active. Passive surveillance relies on routine reporting, is simple and is minimally burdensome to health care providers, but notification is usually not timely or complete enough to be useful. Active surveillance involves targeted searching for cases, and provides more timely and less variable data, which is clearly needed for maternal deaths.
The immediate added value of active surveillance of maternal deaths would include timely notification of events, assessment and confirmation of cases, increased awareness and advocacy, and most importantly accountability for health services, policy makers, managers and civil society for monitoring progress. The term ‘surveillance’ is not new and has been used with reference to maternal health to address maternal death reviews, audits, confidential enquiries, or at demographic surveillance sites [15–17]. However, converting surveillance systems and responses originally developed for communicable and non-communicable diseases for the purpose of eliminating maternal mortality has only recently been adopted as a framework with guidelines for implementation being developed. Not only is MDSR required for accountability, but a clear pre and post-MDG agenda towards eliminating maternal mortality is also needed such as a proposed goal of MMR ≤ 30 per 100,000 by 2030 .
What would MDSR entail?
Pre-requisites for MDSR
First and foremost MDSR requires a mandatory notification of maternal deaths. Steps towards such mandatory notification have taken place in several regions. The Integrated Disease Surveillance and Response (IDSR) guidelines have been updated to include maternal deaths. Several sub Saharan African, Asian and Latin American countries (such as South Africa and Tamil Nadu state in India) have adopted mandatory notification of maternal deaths in the first 48 hours, although full implementation in the context of MDSR is yet to be achieved even in these relatively well developed systems.
Second, for epidemic diseases control, most countries have a national management committee for epidemic and outbreak control: The national management committees are typically headed by a high-level Ministry of Health official with convening power, and includes stakeholders from civil society, community leaders, parliamentarians, security, news and media, finance and education, administration, the donor community, international and national NGOs and UN partners. As described in the recommendations of the Commission on Information and Accountability , this type of national oversight mechanism for maternal, newborn and child health will recommend remedial actions as required. The terms of reference of the national management committee include the development and validation of surveillance and response strategies, coordination of all partners’ contributions and actions, monitoring and evaluating responses. This multi-sector, data driven and action oriented model of national oversight has been missing in most maternal mortality committees.
Establishing a MDSR system
Sample performance indicators of a MDSR system*
Overall system indicators
Maternal death is a notifiable event
National maternal death review committee exists
- that meets regularly
At least quarterly
National maternal mortality report published annually
% of districts with maternal death review committees
% of districts with someone responsible for MDSR
Identification and notification
All maternal deaths are notified
% within 24 hours
% of communities with ‘zero reporting’ monthly
% of community maternal deaths notified within 48 hours
% of expected maternal deaths that are notified
% of hospitals with a review committee
% of health facility maternal deaths reviewed
% of reviews that include recommendations
% of verbal autopsies conducted for suspected maternal deaths
% of notified maternal deaths that are reviewed by district
District maternal mortality review committee exists
- and meets regularly to review facility and community deaths
At least quarterly
% of reviews that included community participation and feedback
Data Quality Indicators
Cross-check of data from facility and community on same maternal death
5% of deaths cross-checked
Sample of WRA deaths checked to ensure they are correctly identified as not maternal
1% of WRA rechecked
% of committee recommendations that are implemented
- quality of care recommendations
- other recommendations
% of committee recommendations that are implemented
National committee produces annual report
District committee produces annual report
- and discusses with key stakeholders including communities
Quality of care (requires specific indicators, such as case fatality rates)
District maternal mortality ratio
Reduced by 10% annually
Hospital maternal mortality ratio/lethality rates
Reduced by 10% annually
MDSR will define the guidelines, tools, mechanisms and indicators for its implementation. MDSR will build on existing surveillance and other information systems at country level. It is critical not to create a parallel system, but one which integrates with existing mechanisms of reporting at country level.
Maternal death case definitions
Death of a woman of reproductive age (WRA):
Death of woman in reproductive years, usually 15–49 years (although some countries may decide to use other reference period years given the importance of teenage pregnancy and early marriage). All death of WRA should be investigated to determine whether the woman was pregnant or within 42 days of the end of a pregnancy.
The death of any woman while pregnant or within 42 days of the termination of pregnancy including deaths where there is a suggestion of a pregnancy even though it may not have been confirmed. In places where the concept of ‘42 days’ may not be well understood the time period can be extended to 2–3 months to ensure that all maternal deaths are captured
All deaths of women while pregnant or within 42 days of the termination of pregnancy exception of those that are easily determined to be caused by incidental or accidental causes (e.g. motor vehicle accidents)
Probable case with ascertainment of cause of death (either using physician ascertainment of medical records or probabilistic modelling of verbal autopsy) and is defined by a death of a woman while pregnant or within 42 days of pregnancy ending, irrespective of the duration and site of the pregnancy, from any cause related to or aggravated by the pregnancy or its management, but not from accidental or incidental causes*
Late maternal death
Death of a woman from direct or indirect obstetric causes more than 42 days but less than one year after termination of pregnancy
Third, develop data collection mechanisms and instruments.
Fourth, investigate through maternal death reviews, verbal autopsies and confidential enquiries.
In a communicable disease surveillance, investigations aim to improve speed (to reduce the toll on mortality and morbidity), and certainty (by establishing determinants and confirming the cause) of causal mechanisms including the agent. In maternal and newborn health, speed is not paramount as there is no contagion, but the confirmation of the maternal death, the determination of causes, determinants and how to prevent future cases remain essential and has to be done in a reasonable time frame. The investigation function is fulfilled by verbal autopsies at community level, maternal death reviews at facility level, and including confidential enquiries into maternal deaths within national mechanisms . The overall goal is to ascertain causes of adverse outcomes of pregnancies and to contribute to improvements in quality of care as summarized in the World Health Organization seminal publication ‘Beyond the numbers’ . The investigation is done by analysing cases of death and identifying clinical, community and health systems factors which have to be addressed to avoid subsequent deaths most importantly, at local (community and facility) level and also at regional and national levels [19, 20]. The UK confidential enquiry into maternal deaths (CEMD) is one of the oldest systems which has been in place for over 50 years, and has been mooted as one of the reasons behind the UK’s success in reducing maternal mortality . A number of other middle income countries, including Malaysia, Sri Lanka, South Africa, Jamaica and Egypt have successfully used confidential enquiries for several years and demonstrated coincident reductions in maternal mortality [21–23]. The US CDC confidential enquiry system has looked to answer specific questions like racial disparities . In most of these countries, relatively reliable death registration systems are available, which have enabled identification of maternal deaths. In other developing countries, investigation into maternal mortality has also been used, for example in The Gambia , in Malawi , and sometimes referred to surveillance, such as in India . The lack of a vital registration system will hamper efforts to identify maternal deaths. In countries with poor vital registration systems, maternal death reviews are used primarily at health facilities, but this may result in biases due to mortality outside health facilities, incomplete data retrieval, especially if registers are not well kept, case notes missing or misplaced and independent sources of verification of death not available. Setting up MDSR will benefit the identification of maternal deaths and therefore provide an enabling environment for establishing solid denominators through birth and death registration systems and thus for maternal death reviews and confidential enquiries into all maternal deaths. The committees will determine the factors that contributed to the maternal death and make recommendations to prevent similar deaths in the future.
Fifth, analyse and interpret data.
Data analysis and interpretation include a simple line listing, descriptive statistics (people, place and time of maternal deaths) as well as case reviews. Confirmation of cases is essential and will be done for deaths in facilities (using patients’ records) as well as in communities (using verbal autopsy data). The required timeliness of the MDSR is likely to involve probabilistic models of verbal autopsy (http://www.interva.net) [27–29], instead of traditional reliance on physicians to assign cause of death on the basis of VA data (difficult in most remote settings in high maternal mortality countries given scarcity of physicians and transaction costs of finding a third physician evaluation when the first two disagree on causes of death).
Sixth, develop dissemination mechanisms.
An important dimension whilst developing MDSR is related to communication. It is paramount to plan for communication before the system is established, the communication of results, the management of crisis (unintended consequences such as rebuttal, denial or denigration for political reasons) and communication for advocacy and resource mobilization.
Seventh, respond by using the MDSR data to implement preventive actions.
This is the most important step, and given the multiplicity of priorities media and governments are often more responsive to catastrophic and tangible news. Although communities, professionals and governments may agree that levels of maternal mortality are unacceptable, they may not have data that spur timely and routine action, or engage the community. Having regular (monthly, quarterly) figures on maternal deaths at facility or district levels and at national level, reviewed by the district level and national management committee for maternal health can prompt countries to set-up an alert system (Figure 3). This regular information should prompt responsiveness, accountability by comparison across years and areas, and between countries in a region of the world. This real-time data can prompt questions about the need for changes, why a community or health facility cannot do better, what the underlying causes are, or whether effective measures have been put in place and evaluated. Among other key issues, MDSR can identify critical gaps in the quality of care provided to pregnant and post-partum women that must be addressed to prevent maternal death. This is the necessary investment to make maternal mortality elimination a national agenda.
Eighth, evaluate the MDSR system.
Given the resources required to set-up and run MDSR, countries should start with basic features, building on existing health information systems. The system will need to be improved subsequently to increase efficiency, and evaluation will identify areas for improvement. In practice, following the classic framework of an evaluation of disease surveillance system is possible. The table below presents sample indicators and performance criteria for the MDSR system and could be adapted to each context. It could include keys steps such as a review of engagement of stakeholders to ensure buy-in and support, the description and review of the operation, attributes (simplicity, flexibility, acceptability, sensitivity, specificity, predictive positive value, representativeness, timeliness), costs, the design of evaluation to be used, and description of data collection, data analysis, report writing, and follow-up of recommendations. The results of the evaluation will be examined by the national oversight committee for maternal and newborn health and appropriate actions will be identified and implemented to improve the surveillance system.
Presentation, format and accuracy of data are critical for mobilising communities and stakeholders and ensuring accountability for reducing maternal deaths. One of the shortcomings of current maternal mortality estimates is the lack of precision, resulting in presentation of point estimates with large confidence intervals. These estimates are often misinterpreted in comparisons of point estimates of maternal mortality ratios with no reference to confidence intervals. Maternal mortality surveillance and response (MDSR) offers a way forward and will improve accurate identification, counting, and reporting of deaths in settings where vital registration systems have low coverage. Most importantly MDSR will improve current estimations of maternal mortality ratios, will provide data for action to improve quality of care and reduce maternal deaths. MDSR will enhance accountability mechanisms by providing information on whether policies and actions meant to reduce maternal mortality are effective. Having data at sub-national level for action and accountability will also provide better opportunities for equity-based interventions. This paper presents the different components and steps for implementing MDSR. Countries are at various stages of health systems development and will implement MDSR differently based on levels of mortality and health service factors. Regardless of the variations in countries’ contexts, accountability requires a bold investment towards maternal mortality elimination with a possible goal of an MMR ≤ 30 per 100,000 by 2030 . Implementing and improving completeness of MDSR and establishing solid denominators through birth and death registration systems will be achieved over time, but a journey that does not get started can never be completed.
The views expressed in this publication are solely those of the authors.
- Ronsmans C, Graham WJ: Lancet Maternal Survival Series steering group: Maternal mortality: who, when, where, and why. Lancet. 2006, 368 (9542): 1189-1200. 10.1016/S0140-6736(06)69380-X.View ArticlePubMedGoogle Scholar
- Commission on information and accountability for Women’s and Children’s Health:http://www.everywomaneverychild.org/images/content/files/accountability_commission/final_report/Final_EN_Web.pdf,
- Danel I, Graham WJ, Boerma T: Maternal death surveillance and response. Bull World Health Organ. 2011, 89 (11): 779-10.2471/BLT.11.097220. 779AView ArticlePubMedPubMed CentralGoogle Scholar
- WHO: Maternal deaths surveillance and response: technical guidance (forthcoming).Google Scholar
- Gilmore K, Gebreyesus TA: What will it take to eliminate preventable maternal deaths?. Lancet. 2012, 380 (9837): 87-88. 10.1016/S0140-6736(12)60982-9.View ArticlePubMedGoogle Scholar
- Muleta M, Rasmussen S, Kiserud T: Obstetric fistula in 14,928 Ethiopian women. Acta Obstet Gynecol Scand. 2010, 89 (7): 945-951. 10.3109/00016341003801698.View ArticlePubMedGoogle Scholar
- Etard JF, Kodio B, Ronsmans C: Seasonal variation in direct obstetric mortality in rural Senegal: role of malaria?. Am J Trop Med Hyg. 2003, 68 (4): 503-504.PubMedGoogle Scholar
- Anya SE: Seasonal variation in the risk and causes of maternal death in the Gambia: malaria appears to be an important factor. Am J Trop Med Hyg. 2004, 70 (5): 510-513.PubMedGoogle Scholar
- Hounton SH, Sombie I, Townend J: The tip of the iceberg: evidence of seasonality in institutional maternal mortality and implications for health resources management in Burkina Faso. Scand J Public Health. 2008, 36 (3): 310-317. 10.1177/1403494807085361.View ArticlePubMedGoogle Scholar
- Hogan MC, Foreman KJ, Naghavi M: Maternal mortality for 181 countries, 1980–2008: a systematic analysis of progress towards Millennium Development Goal 5. Lancet. 2010, 375: 1609-1623. 10.1016/S0140-6736(10)60518-1.View ArticlePubMedGoogle Scholar
- Graham WJ, Braunholtz DA, Campbell OMR: New modeled estimates of maternal mortality. Lancet. 1963, 2010: 375-Google Scholar
- Byass P: The imperfect world of global health estimates. PLoS Med. 2010, 7: e1001006-10.1371/journal.pmed.1001006.View ArticlePubMedPubMed CentralGoogle Scholar
- Thomsen S, Phuong Hoa DT, Målqvist M: Promoting equity to achieve maternal and child health. Reproductive Health Matters. 2011, 19 (38): 1-7.View ArticleGoogle Scholar
- Teutsch SM, Churchill RE: Principles and practice of public health surveillance. 1994, Oxford University Press, USA, 19-69.Google Scholar
- Gregg M: Field epidemiology. 1996, Oxford University Press, New-York, USAGoogle Scholar
- Lewis G, Drife J: Why mothers die: report of the confidential enquiry into maternal deaths in the United Kingdom 1994–96. 1998, Stationery Office, LondonGoogle Scholar
- Chang J, Elam-Evans LD, Berg CJ: Maternal mortality surveillance, United States, 1991–1999. MMWR. 2003, 52 (SS02): 1-8.PubMedGoogle Scholar
- Sombie I, Meda N, Hounton S, Bambara M, Ouedraogo TW, Graham W: Missing maternal deaths: lessons from Souro Sanou University Hospital in Bobo-Dioulasso, Burkina Faso. Trop Doct. 2007, 37 (2): 96-98. 10.1258/004947507780609239.View ArticlePubMedGoogle Scholar
- World Health Organization: Beyond the numbers: reviewing maternal deaths and complications to make pregnancy safer. 2004, World Health Organization, GenevaGoogle Scholar
- Hussein J: Improving the use of confidential enquiries into maternal deaths in developing countries. Bulletin of the World Health Organization. 2007, 85 (1): 68-69. 10.2471/BLT.06.033506.View ArticlePubMedPubMed CentralGoogle Scholar
- Pathmanathan I, Liljestrand J, Martins JM, Rajapaksa L, Lissner C, de Silva A, Selvaraju S, Singh PJ: Investing in maternal health: Learning from Malaysia and Sri Lanka (Health, Nutrition and Population Series). 2003, The World Bank, Washington DC, USAGoogle Scholar
- Reducing maternal mortality: Lessons from Bolivia, China, Egypt, Honduras, Indonesia, Jamaica, and Zimbabwe. Edited by: Koblinsky M. 2003, The World Bank, Washington DC, USAGoogle Scholar
- Graham WJ, Hussein J: Universal Reporting of Maternal Mortality: An achievable goal?. Int J Gynaecol Obstet. 2006, 94: 234-242. 10.1016/j.ijgo.2006.04.004.View ArticlePubMedGoogle Scholar
- Walraven G, Telfer M, Rowley J: Maternal mortality in rural Gambia: levels, causes and contributing factors. Bulletin of the World Health Organization. 2000, 78: 603-613.PubMedPubMed CentralGoogle Scholar
- Bicegoa G, Boerma T, Ronsmans R: The effect of AIDS on maternal mortality in Malawi and Zimbabwe. AIDS. 2002, Vol 16 (No 7): -Google Scholar
- Barnett S, Nair N, Tripathy P: A prospective key informant surveillance system to measure maternal mortality - findings from indigenous populations in Jharkhand and Orissa, India. BMC Pregnancy and Childbirth. 2008, 8: 6-10.1186/1471-2393-8-6.View ArticlePubMedPubMed CentralGoogle Scholar
- Fottrell E, Kahn K, Tollman S: Probabilistic Methods for Verbal Autopsy Interpretation: InterVA Robustness in Relation to Variations in A Priori Probabilities. PLoS One. 2011, 6 (11): e27200-10.1371/journal.pone.0027200.View ArticlePubMedPubMed CentralGoogle Scholar
- Fottrell E, Byass P, Ouedraogo TW: Revealing the burden of maternal mortality: a probabilistic model for determining maternal causes of death from verbal autopsies. Popul Health Metr. 2007, 8 (5): 1-View ArticleGoogle Scholar
- Byass P, Hounton S, Ouédraogo M: Direct data capture using hand-held computers in rural Burkina Faso: experiences, benefits and lessons learnt. Trop Med Int Health. 2008, 13 (Suppl 1): 25-30.View ArticlePubMedGoogle Scholar
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