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Volume 14 Supplement 3

Proceedings from the Global Forum on Bioethics in Research (GFBR)’s “Ethics of Research in Pregnancy” meeting


Publication of this supplement has been funded by the Wellcome Trust. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editors would like to acknowledge the work of Katherine Littler and Adrienne Hunt, Wellcome Trust, to make this issue possible, and we would like to thank Maureen Kelley, Ethox Centre, and Joe Millum, National Institutes of Health, for their work in supporting the development of the case studies included in this Supplement. The Supplement Editors declare no competing interests.

Buenos Aires, Argentina03-04 November 2016

Edited by Maggie Little and Marisha Wickremsinhe

  1. Despite a global need for the use of medication during pregnancy, the medical research community lacks robust evidence for safety and efficacy of treatments and preventives often taken by pregnant women. Given...

    Authors: Margaret Olivia Little and Marisha N. Wickremsinhe

    Citation: Reproductive Health 2017 14(Suppl 3):156

    Content type: Introduction

    Published on:

  2. Pregnant women experience unique physiological changes pertinent to the effective prevention and treatment of common diseases that affect their health and the health of their developing fetuses. In this paper,...

    Authors: Barbara J. Sina

    Citation: Reproductive Health 2017 14(Suppl 3):170

    Content type: Research

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  3. Scarce research with pregnant women has led to a dearth of evidence to guide medical decisions about safe and effective treatment and preventive interventions for pregnant women and their potential offspring. ...

    Authors: Carla Saenz, Phaik Yeong Cheah, Rieke van der Graaf, Leslie Meltzer Henry and Anna C. Mastroianni

    Citation: Reproductive Health 2017 14(Suppl 3):173

    Content type: Research

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  4. The exclusion of pregnant women from health research remains a significant challenge globally. In settings where cultural traditions and gender norms support a more restricted decision-making role for women in...

    Authors: Kenneth Ngure, Susan Brown Trinidad, Kristin Beima-Sofie, Jared M. Baeten, Nelly R. Mugo, Elizabeth A. Bukusi, Renee Heffron, Grace John-Stewart and Maureen C. Kelley

    Citation: Reproductive Health 2017 14(Suppl 3):160

    Content type: Research

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  5. Informed consent is the heart of ethical research. For any consent to be ethically valid, it should meet certain critical criteria— disclosure and understanding of relevant information, decision making compete...

    Authors: Hema Dhumale and Shivaprasad Goudar

    Citation: Reproductive Health 2017 14(Suppl 3):166

    Content type: Research

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  6. Laos has the highest maternal mortality ratio in mainland Southeast Asia but there has been little research conducted with pregnant women. We aim to discuss ethical challenges in enrolling pregnant women in re...

    Authors: Vilada Chansamouth, Rose McGready, Danoy Chommanam, Soukanya Homsombath, Mayfong Mayxay and Paul N. Newton

    Citation: Reproductive Health 2017 14(Suppl 3):167

    Content type: Research

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  7. For 30 years, women have sought equal opportunity to be included in trials so that drugs are equitably studied in women as well as men; regulatory guidelines have changed accordingly. Pregnant women, however, ...

    Authors: Melba F. Gomes, Vânia de la Fuente-Núñez, Abha Saxena and Annette C. Kuesel

    Citation: Reproductive Health 2017 14(Suppl 3):172

    Content type: Research

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  8. Research during pregnancy is affected by multiple ethical challenges which have not received sufficient international attention and consideration from the bioethics, clinical, and policymaking communities work...

    Authors: Adrienne Hunt, Natalie Banner and Katherine Littler

    Citation: Reproductive Health 2017 14(Suppl 3):158

    Content type: Commentary

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